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Drug Kinetics – Multimedia

Model-Based Approaches to DDI Risk Prediction-Transitioning from In Vitro Data to In Silico Modeling content piece image
Video

Model-Based Approaches to DDI Risk Prediction-Transitioning from In Vitro Data to In Silico Modeling

This informative ADME 101 discusses In Vitro to In Vivo Extrapolation (IVIVE) and how a model-based approach following routine perpetrator potential studies (i.e. CYP inhibition, CYP induction, and transporter inhibition) assessing clinical potential may eliminate the need of conducting clinical studies.
Microflow Chromatography: A Key to More Sensitive Metabolite Identification content piece image
App Note / Case Study

Microflow Chromatography: A Key to More Sensitive Metabolite Identification

In early-stage pharmaceutical research, knowledge of a compound’s metabolism can assist in the identification of structural liabilities that can contribute to non-optimal pharmacokinetics, potentially toxic breakdown products or the potential for drug-drug interactions.
Advances in High Throughput Analysis of In-Vitro Drug Screening Using the Novel Echo® MS System content piece image
Video

Advances in High Throughput Analysis of In-Vitro Drug Screening Using the Novel Echo® MS System

Speaking at Advances in Drug Discovery & Development online symposium 2021, Rolf Kern from SCIEX, presented his talk on the new Echo MS system.
ADME 101 Drug Transporter Studies: Lysosomal Trapping Webinar content piece image
Video

ADME 101 Drug Transporter Studies: Lysosomal Trapping Webinar

This ADME 101 video discusses how compounds can become trapped by lysosomes, which can lead to high organ-to-blood ratios and mistaken for active drug transport, how concomitant administration of lysosomotropics could lead to elevated drug exposure levels, and how accumulation of lipophilic amines can lead to drug-induced phospholipidosis due to decreased phospholipid catabolism.
ADME 101 Guide to Subcellular Fractions and When to Use Which Test System content piece image
Video

ADME 101 Guide to Subcellular Fractions and When to Use Which Test System

This ADME 101 video provides an overview of different types of subcellular fractions, such as microsomes, S9, cytosol, lysosomes and homogenate, and their unique benefits for use in various types of in vitro ADMET/DMPK & Drug-Drug Interaction studies.
ADMET in Drug Discovery With Dr. Andrew Mtewa content piece image
Video

ADMET in Drug Discovery With Dr. Andrew Mtewa

In this Teach Me in 10 episode, Lucy Lawrence is joined by Dr. Andrew Mtewa, senior lecturer in chemistry at the Malawi University of Science and Technology.
Human Organs-on-Chips for Disease Modeling, Drug Development and Personalized Medicine content piece image
Video

Human Organs-on-Chips for Disease Modeling, Drug Development and Personalized Medicine

Speaking at the online symposium, Innovations in Disease Modeling 2022, Dr. Donald E. Ingber, Founding Director of Wyss Institute for Biologically Inspired Engineering at Harvard University, presented his talk on novel human organ-on-a-chip technologies
Role of Sulfotransferases in Drug Metabolism and Potential for Drug Drug Interactions content piece image
Video

Role of Sulfotransferases in Drug Metabolism and Potential for Drug Drug Interactions

Continuing our series on non-CYP-mediated metabolism pathways, we will be discussing another of the most requested enzymes: Sulfotransferases (SULTs). SULTs participate in Phase 2 metabolism of xenobiotics in humans and are characterized by the abundance and broad tissue distribution of the enzymes. Gene regulation and genetic polymorphism of SULTs also contribute to our understanding of the significance of these enzymes in the process of drug development.
<i>In Vitro</i> DDI Drug Transporter Studies | ADME 101 Webinar: Efflux and Uptake Transporters content piece image
Video

In Vitro DDI Drug Transporter Studies | ADME 101 Webinar: Efflux and Uptake Transporters

Drug transport can be thought of as the AD&E in ADME, as transporters are responsible for absorption, distribution, tissue-specific drug targeting, and elimination of drugs. Since they are involved in so much of the movement of a compound through the body, they can be involved in many drug‒drug interactions (DDI). The clearance of transporter substrates can be impacted by transporter inhibitors or inducers which can lead to toxicity or loss of efficacy.
Drug Discovery and Design content piece image
eBook

Drug Discovery and Design

Download this eBook to explore automation in drug discovery, therapeutic targets, drug delivery, novel approaches to treatment and various screening strategies.
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