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Drug Kinetics – Multimedia

Binding Kinetics in Drug Discovery content piece image
eBook

Binding Kinetics in Drug Discovery

Binding kinetic research is both beneficial and critical for successful drug discovery research. In this eBook, we delve into the role of binding kinetics in pharmacology, methods for measuring kinetic parameters, and applications.
DonorPlex™ Pooled Donor Human Hepatocytes Enable the Next Level of Reliability | Lonza content piece image
Video

DonorPlex™ Pooled Donor Human Hepatocytes Enable the Next Level of Reliability | Lonza

Watch our expert, Maureen Bunger, PhD, explain how our patented manufacturing process ensures that the DonorPlex™ Hepatocytes exhibit improved phenotype reproducibility.
Underprediction of Drug Clearance by Aldehyde Oxidase (AO)–Mediated Drug Metabolism (Webinar) content piece image
Video

Underprediction of Drug Clearance by Aldehyde Oxidase (AO)–Mediated Drug Metabolism (Webinar)

Aldehyde oxidase (AO) enzyme has gained increasing attention in drug development as one of the alternative approaches to reduce P450-mediated drug metabolism liability. However, clinical failure due to poor prediction of AO-mediated clearance is a major hurdle in development of drugs that are AO substrates.
Fundamentals of Therapeutic Drug Monitoring: Definition, Importance and Methods content piece image
Listicle

Fundamentals of Therapeutic Drug Monitoring: Definition, Importance and Methods

Download this listicle to discover answers to key questions such as: can therapeutic drug monitoring (TDM) be used for all drugs? Which drugs are currently monitored using TDM approaches? What analytical methods are used for TDM?
Webinar: Red Blood Cell Partitioning Studies to Improve Accuracy in Pharmacokinetics (PK) Calculations content piece image
Video

Webinar: Red Blood Cell Partitioning Studies to Improve Accuracy in Pharmacokinetics (PK) Calculations

In this webinar, SEKISUI XenoTech study director Dr. Steven McGreal will cover study design elements and other considerations like timing and characteristics of drugs with high RBC partitioning. He will discuss impacts on PK calculations and provide examples of how RBC partitioning rates can cause errors downstream if not properly investigated early in drug development.
Preparation of Buffers and Solutions for Therapeutic Antibody Analysis content piece image
App Note / Case Study

Preparation of Buffers and Solutions for Therapeutic Antibody Analysis

Antibodies are subject to instability issues due to chemical and physical instabilities and these effects can change the pharmacokinetics of the antibody. For this reason, produced antibodies must be thoroughly tested before they can be applied for treatment of patients.
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Listicle

Drug–Target Binding: Recent Research Developments

Being able to accurately predict drug–target interactions (DTIs) and drug–target binding affinity (DTBA) is crucial in early drug development and during drug repurposing endeavors. Here, we look at some recent research developments in this space.
An Overview of Non CYP Mediated Metabolism Pathways and <i>In Vitro</i> Evaluation Strategies content piece image
Video

An Overview of Non CYP Mediated Metabolism Pathways and In Vitro Evaluation Strategies

Although cytochrome P450 (CYP)-mediated metabolism continues to be of major importance for a large proportion of small molecule new drug candidates, various methods in recent decades have accelerated the development of drug candidates with significant non CYP-mediated metabolism.
Kinetics in Drug Discovery content piece image
eBook

Kinetics in Drug Discovery

Drugs elicit their desired therapeutic effects by interacting with specific disease-related targets. However, to determine exactly how a drug works inside the body it is important to address key questions. What type of drug is being used? How is it being administered? What are the characteristics of the individual taking the drug?
2C or Not 2C: CYP2C Induction Studies for Successful Preclinical Risk Assessment (Webinar) content piece image
Video

2C or Not 2C: CYP2C Induction Studies for Successful Preclinical Risk Assessment (Webinar)

This webinar will focus on CYP2C induction and will emphasize when to include CYP2C induction in a study, how to design the study to generate meaningful data and meet the regulatory requirements, what endpoints to measure, and how to interpret results.
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