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Drug Targets – News and Features

Double helix structure of DNA.
News

Ancestral Differences Affect Performance of CRISPR-Cas9 Guides in Human Cells

New research shows that many of these CRISPR screening experiments rely on components, called CRISPR/Cas9 guides, that do not perform equally well in cells from people of all ancestries, which can cause CRISPR screens to miss cancer dependencies.
Tumor microenvironment.
News

“Unexpected” Kidney Cancer Drug Resistance Mechanism Uncovered

For nearly two decades, how kidney cancer becomes resistant to rapalog drugs has baffled the scientific community. Now a study by researchers at UT Southwestern Medical Center’s Kidney Cancer Program sheds light
Drugs of different colors, shapes and sizes in half-filled blister packs.
News

Blood Clot-Targeting Drug Candidates Developed Through Computer-Aided Design

A team of researchers has created a new series of drug candidates against a hard-to-target receptor involved in the formation of blood clots.
Pink and blue, white and red pill capsules on a white background.
News

Peptidomimetics Creates New Possibilities in Drug Discovery

Researchers have successfully demonstrated how peptides can be modified to make them promising reagents for drug discovery and diseases diagnostics.
A strand of RNA.
News

Novel Method Unveils Cellular Coordination of Gene Transcription

By capturing short-lived RNA molecules, scientists can map relationships between genes and the regulatory elements that control them.
Growth factors trigger G proteins (in green) to disengage from GPCRs and change localization within cells. At right: A ribbon diagram of the G protein structure shows the position of all phosphoevents the “buzzer” site in red.
News

Researchers Identify “Short Circuits” in Cellular Pathways

A group of researchers at University of California San Diego has identified the cause of a “short-circuit” in cellular pathways, a discovery that sheds new light on the genesis of a number of human diseases.
Scientist in a lab coat holding a large red and white drug capsule. Inside the drug is a molecular structure and yellow futuristic-looking dots.
Article

Implementing AI in Drug Discovery

The four main considerations that any leader should take into account to successfully implement AI in their organization are explored here.
Therapeutic drugs next to a stethoscope and target with a dart in the bullseye.
Industry Insight

Expanding the Druggable Space With Degradation-Based Therapies

We spoke with Dr. Christian Dillon to learn more about degradation-based therapies, the challenges associated with their discovery and how innovative solutions are helping to realize the potential of this promising class of therapeutics.
Female scientist tapping on a digital tablet performing pharmaceutical industry research and data analysis
Industry Insight

Collaborative AI Partnership Hopes To Shape the Future of Drug Discovery

Sanofi, Formation Bio and OpenAI are collaborating to build AI-powered software to accelerate drug development. The three teams will combine data, software and tuned models to develop custom, purpose-built solutions for drug discovery.
Photograph of a pregnant woman holding her stomach
News

Placenta Map Reveals Source of Infection-Related Pregnancy Complications

Researchers using “mini placentas” from human samples have created the first map of human placenta infection pathways. This could highlight potential drug targets to develop pregnancy-safe therapies for preventing severe pregnancy complications.
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