Drug Targets – News and Features

A new study confirms that an "Alzheimer's in a dish" model can mimic brain function and gene expression patterns, making it ideal for assessing new drugs as well as finding new targets.

RNA therapeutics promise rapid, personalized and flexible treatments against multiple diseases. In this article, we will explore whether RNA therapeutics can realize their full potential.

Researchers have used whole-genome CRISPR interference screening to identify the “Achilles Heel” of drug-resistant tuberculosis and identify drugs that target these weaknesses to rapidly kill drug-resistant strains.

New research describes how sphingolipids can also contribute to arterial plaques and atherosclerosis, revealing a new side to cardiovascular disease.

Using cerebrospinal fluid, researchers have identified proteins and genes linked to Alzheimer's progression that could form drug targets.

A new weight loss drug target could lower appetite and increase energy expenditure without causing nausea as a side effect.

University of California, Riverside scientists have designed novel agents that bind to and degrade Pin1, a protein linked to pancreatic cancer. These “molecular crowbars” destabilize Pin1, making it vulnerable to degradation.

New research shows that microglia, which usually clear debris, cause harmful inflammation in the presence of APOE4 protein.

Scientists at UC Davis discovered new gene expression clusters in the amygdala of humans and non-human primates, enhancing understanding of emotional disorders. This research may open pathways for developing targeted therapies for anxiety.

Researchers have designed a small molecule that holds promise as a cancer therapeutic, activating the apoptosis cascade in tumor cells while sparing healthy cells.