Electrophysiology – Multimedia

Some Breaking Neuroscience Stories.

HumSilencer removes the most common source of background noise in electrophysiology experiments. This App note explains how.

Michael Nestor gives you a simplistic overview of what equipment you might need or encounter when setting up a single-cell patch clamp rig for whole-cell patch and electrophysiological recordings from neurons.

These results support the use of hSC-CM and MEA technology for preclinical assessment of proarrhythmic risk within the proposed CiPA paradigm, and, more generally, demonstrate that automation of the CM-MEA assay can achieve high reliability and throughput for cardiac risk assessment in vitro.

Electrophiles can bind through reversible or irreversible reactions based on the structure of the compound. Here, patch clamp techniques and calcium imaging have been used to characterize human TRPA1 (hTRPA1) channel activity (expressed in HEK293 cells) in the presence of reversible and irreversible electrophiles

This protocol describes the preparation of hippocampal slice and electrophysiology recording.

This presentation will describe the critical role of human stem cell derived cardiomyocytes in the CiPA initiative, lessons learned as the project moves towards completion, along with their future role in preclinical cardiac safety testing.

The functional network of human induced pluripotent stem cell (hiPSC)-derived neurons is a potentially powerful in vitro model for evaluating disease mechanisms and drug responses. However, the culture time required for the full functional maturation of individual neurons and networks is uncertain. We investigated the development of spontaneous electrophysiological activity and pharmacological responses for over 1 year in culture using multi-electrode arrays (MEAs).

This document provides detailed information about triggering with the Leica TCS SP5, TCS SP5 II and DM6000 CFS systems.

Human iPS-derived hepatocytes (ReproHepato™) and cardiomyocytes (ReproCardio 2™) are useful for in vitro toxicity assays.