Pharmacovigilance – Multimedia

Cancer immunotherapy relies on activating or enhancing the antitumor immune response and has taken a central position in cancer treatment modalities. However, not all patients respond to immunotherapy, and combination immunotherapies increase cost of treatment and heighten the risk for toxicity-related adverse events.

This talk will discuss processes for the metabolism of a drug, referred to as ADME (Absorption, Distribution, Metabolism, Excretion), and the safety testing to provide requisite information to move a drug through IND and into clinical trials. Prior to marketing a new drug and actually prior to administering a candidate drug to humans in clinical trials, it is important to ensure that drug will not only be effective in the therapeutic manner prescribed, but also be safe and not bring any undo harm to patients.

Delivering drugs directly to cancer cells could help reduce the unpleasant side effects of chemotherapy.

The importance of glucuronidation for metabolism of xenobiotics in humans is illustrated by the abundance and broad tissue distribution of the enzymes, the diversity of substrates and reactions catalyzed, as well as a number of distinctive UGT enzymes and their genetic polymorphisms.

By recreating many of the cell-cell and cell-matrix interactions found in native tissues, spheroids and organoids provide more physiologically accurate models of disease and development than traditional 2D cultures.

Recently, the advantages of PHH liver spheroids use in liver toxicity tests over the traditional 2D monolayer culture of PHHs has been demonstrated by many scientists.

Treatments using psychedelics are making waves in psychiatric medicine. In this article, we explore the background, mechanisms of action and therapeutic applications of four leading psychedelic drugs.

Development of a manufacturing process for a biotherapeutic that ensures consistent quality, purity and safety is a critical step in successfully developing the drug, getting it approved by regulatory agencies, and bringing it to the market.

Pharmaceutical analysis in drug development mainly focuses on methods to identify and quantify potential new drug candidates. It is imperative that effective, robust methods are used to maintain the safety of the product.

Cancer immunotherapy relies on activating or enhancing the antitumor immune response and has taken a central position in cancer treatment modalities. However, not all patients respond to immunotherapy.