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The Immune System – Multimedia

Application of 1H NMR Metabolomics to a Murine Model of Inflammatory Arthritis content piece image
Poster

Application of 1H NMR Metabolomics to a Murine Model of Inflammatory Arthritis

The novel quantitative technique of "Targeted Profiling" of 1H 1D NMR data is applied to a unique model of rheumatoid arthritis. A number of candidate biomarkers not previously identified using NMR techniques are identified related to inflammation and immune response. The pharmaceutical relevance of several of these metabolites is discussed.
A Novel Array-Based Assay for the Detection of IgG-Mediated Food Intolerance  content piece image
Poster

A Novel Array-Based Assay for the Detection of IgG-Mediated Food Intolerance

The Genarrayt 200+ Foods IgG test comprises of glass slides onto which 16 microarrays of over 200 different foods have been printed. Each microarray includes standards for quantitation and positive and negative controls for quality control. Food IgGs are detected by a novel fluorescent dye labelled anti-human IgG conjugate and results are measured using a laser scanner. Fluorescence intensity is directly proportional to antibody activity in the sample.
Clinical Validation of a Protein Microarry Assay for Diagnostics of Autoimmune Disease content piece image
Poster

Clinical Validation of a Protein Microarry Assay for Diagnostics of Autoimmune Disease

We have developed an autoantigen microarray that will allow laboratories to measure the presence of autoantibobies associated with different collagenois and vasculitis-related autoimmune diseases for a single serum sample.
Identification of Chemokines and Cytokines Involved in the Migration of MSC to Bone Marrow as Well as to Damaged Tissues content piece image
Poster

Identification of Chemokines and Cytokines Involved in the Migration of MSC to Bone Marrow as Well as to Damaged Tissues

Recent in vivo studies have demonstrated that transplanted MSC in mice were able to migrate into various tissues including lung, brain, bone marrow, heart and many others. Nevertheless, mechanisms responsible for the MSC migration remain unclear.
Combined Immune Parameters and X-ray data in Early Prediction of Anti-Tuberculosis Chemotherapy Response content piece image
Poster

Combined Immune Parameters and X-ray data in Early Prediction of Anti-Tuberculosis Chemotherapy Response

20 tuberculosis (12 slow-responders and 8 fast responders) patients were treated with directly observed short course anti-tuberculosis chemotherapy. Chest X-ray was performed. sICAM-1 and suPAR were measured in serum by ELISA, TNFRs using the luminex technology. General discrimination analysis on selected analytes gave, 91.66% and 87,50% correctly classify fast responders and slow responder respectively. The support vector machine analysis gave 100% correct classification.
Determination of Interferon-Pathway–Related Gene Induction during RNAi  content piece image
Poster

Determination of Interferon-Pathway–Related Gene Induction during RNAi

Experimental approaches using short interfering RNA (siRNA) molecules to specifically silence gene expression have become more widely used in recent years. As for all techniques in molecular and cellular biology, the importance of protocol optimization and the use of appropriate controls cannot be overestimated.
Application of Microarrays in Process Analytical Technologies A First Step Towards Real Time Product Release content piece image
Poster

Application of Microarrays in Process Analytical Technologies A First Step Towards Real Time Product Release

Application of microarrays during process development helps to gain insight in biological processes involved in product formation, increasing process understanding.
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