The Immune System – News and Features

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Protein Behind Psoriasis Flare-Ups Identified for the First Time
The protein behind flare-ups of psoriasis and its link to the immune system have been uncovered.

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Study Finds No Evidence CAR T-Cell Therapy Causes Secondary Cancers
A study of 783 patients treated with CAR T cell therapy found no evidence that the therapy itself caused secondary cancers. Researchers confirmed that rare cases of cancer were linked to prior treatments like chemotherapy, not CAR T therapy.

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Gene Therapy Shows Promise for Rare Bone Disease in Mice
Researchers have developed a gene therapy that may provide a long-term treatment for hypophosphatasia. Unlike current therapies requiring frequent injections, this approach delivers a single dose to restore bone mineralization.

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COVID-19 Infections Linked to Faulty Proteins in the Brain
Researchers found that COVID-19 is linked to increased biomarkers associated with Alzheimer’s disease, particularly in those hospitalized or with risk factors like high blood pressure.

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3D Model Accurately Mimics the Blood–Brain Barrier
A 3D model has been developed that accurately replicates the complex structures of cerebral blood vessels, enabling researchers to mimic the blood–brain barrier.

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Understanding Endosomal Recycling Could Lead to New Disease Therapies
Researchers at UT Southwestern identified how SNX17 and Retriever interact to regulate endosomal recycling, a crucial process for protein transport. Using cryo-EM imaging, they revealed a key binding mechanism.

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Brain Immune Cells in High-Risk Individuals React Differently to Alcohol
Rutgers researchers discovered that microglia from individuals with a high genetic risk for alcohol use disorder (AUD) are more active after alcohol exposure, pruning more neural connections.

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Targeted Therapy Shows Effectiveness in Skin Disease Patients
Mayo Clinic researchers have identified a targeted therapy that could bring relief to people living with lichen planus, a chronic inflammatory skin condition of the skin, hair, nails, mouth and genitals.

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Regulatory Immune Cells Regenerate the Thymus Following Cancer Therapy
Researchers have demonstrated a way to boost thymic function after damage using a specific type of regulatory T cell.

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How an Effective Cancer Therapy Was Redesigned To Make It Safer
UIC researchers have redesigned asparaginase, a key leukemia treatment, to reduce severe side effects like liver damage and blood clots. The modified enzyme is more effective and may treat other cancers like melanoma.
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