In an era when resequencing crop genomes has become easy, relatively cheap and commonplace, we are finally in a position to understand the function of nearly every gene in the genome and the effect each has on traits of agronomic or economic interest. A sequence indexed, searchable, saturated collection of mutants allows breeders to pursue a much more informed approach to improving important traits. In turn, that information allows us to explore and mine the natural genetic diversity for specific genes of interest in breeding programs. This huge amount of information, and the pipelines that lead to it, prove to be complex and somewhat user-unfriendly. While that presents great opportunity for the earliest movers, optimization of growth and production in food and fuel crops, in the global sense, will only come when both the information and the training in its routine application are in the hands of breeders worldwide in a useful form. Those most familiar with the natural diversity of crop species and the sometimes subtle, phenotypic differences among locally adapted breeding stock are often unable to tap into valuable and important information that can help them understand and develop their materials and promote germplasm exchange. We are trying to change that paradigm.
Moving from Functional Genomics to Functional Improvement in Sorghum
Video Nov 25, 2014
The PromethION is Oxford Nanopore Technologies' largest sequencing device, capable of delivering many terabases of data, in real time, from a single run. Hear how teams across a broad range of applications, based in labs all over the world — US (UCSF, UCD, JCVI and UCSC), China (GrandOmics and Biomarker) and Europe (KeyGene, Genescope and UMC Utrecht) — are using PromethION in their work.WATCH NOW
Professor Sir Doug Turnbull from the Wellcome Trust Centre for Mitochondrial Research at the University of Newcastle explains his research into mitochondrial donation, the innovative treatment that hopes to stop faulty mitochondria being passed on from mother to child to prevent incurable genetic diseases.
The first babies conceived with this treatment through IVF may be born in the UK soon.