Principles of Isothermal Titration Calorimetry (ITC)

As part of the London Proteomics Discussion Group webinar series: "SARS-CoV-2: What role can proteomics play?" Dr Münch presented his work on changes in response to SARS-CoV-2 infection, highlighting potential therapies.

When a cell divides to make new cells, the chromosomes normally stay the same. But sometimes mistakes happen. With Philadelphia positive leukemia, a gene called the ABL1 gene on chromosome 9 breaks off and sticks to a gene called the BCR gene on chromosome 22. It produces a new gene called BCR-ABL1 which causes the cell to make too much of a protein called tyrosine kinase. This protein encourages leukemia cells to grow and multiply.

This video describes how whole genome sequencing is used to track pathogens as they spread from person to person on the path to a foodborne or infectious disease outbreak.