PromethION in action, in labs around the world

Oxford Nanopore Technologies has developed nanopore-based DNA and RNA sequencing technology designed to provide on-demand biological information, to any person, in any environment.

This animation depicts how Cas13—a CRISPR-associated protein—may be adapted to detect human disease. This new diagnostic tool, called SHERLOCK, targets RNA (rather than DNA), and has the potential to transform research and global public health.

Watch how the jiggling motion of bacterial DNA stops when a natural antimicrobial peptide permeates the E. coli membrane. This novel mechanism helps explain why bacteria develop resistance very slowly and may inform the design of new antimicrobial agents.