Analytical Strategies To Conduct Oligonucleotide Stability Studies and Bioanalysis
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Session One: October 23, 2025 I 8am PDT, 11am EDT, 4pm BST, 5pm CET
Session Two: October 24, 2025 I 9am CST, 10am JST, 11am AEDT
Synthetic oligonucleotides are transforming modern therapeutics and advanced analytical strategies are driving confident decision-making to ensure safe and effective development of oligonucleotide drugs.
This webinar will cover chemical stability assessment and bioanalytical quantitation strategies, presenting a forced degradation study of an antisense oligonucleotide under thermal and oxidative stress. The approach enables precise identification of degradation products and sequence validation, supporting regulatory compliance and informed drug development.
The session will also explore the benefits of automated sample preparation combined with high-sensitivity mass spectrometry for oligonucleotide bioanalysis. Through real-world case studies, our speakers will demonstrate reliable quantitation from complex biological matrices, showcasing workflow efficiency and analytical performance.
Attend this webinar to:
- Understand how forced degradation studies reveal oligonucleotide stability profiles under thermal and oxidative stress conditions
- Discover how advanced analytical workflows enable accurate identification of degradation products, supporting regulatory compliance in therapeutic development
- Learn how to fully automate a bioanalysis workflow for oligonucleotides
