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Improved Mutation Detection With Targeted Sequencing

Improved Mutation Detection With Targeted Sequencing content piece image

Viruses mutate rapidly and hundreds of mutations have been detected in the SARS-CoV-2 genome, some of which can increase infection rates as recently reported for the novel strain B1.1.7. Novel mutations can also affect the accuracy of diagnostic tests, the efficiency of vaccines, and may associate with clinically relevant phenotypes (disease severity, response to treatment). 

Viral whole genome sequencing can readily reveal novel mutations and thereby contribute to an improved understanding of virulence and the reconstruction of worldwide transmission routes.

Watch this webinar to learn about:

  • Benchmarking of various approaches for complete sequencing of the SARS-CoV-2 genome 
  • Characterization of intrahost viral diversity and evolution, and the detection of low-frequency viruses in a host's SARS-CoV-2 population
  • An approach combining the Twist SARS-CoV-2 panel with ultra-deep sequencing, unique molecular barcodes, and a newly developed SNV detection method that outperforms other approaches
Prof Dr Stephan Ossowski
Prof Dr Stephan Ossowski