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Overcoming Downstream Purification Challenges for Viral Vector Manufacturing

Adeno-associated virus (AAV) has shown great potential as a delivery vector for therapeutic genes and is becoming a tool of choice for many emerging gene therapies. As more and more excellent clinical outcomes are being reported, the current potential of viral vectors in the clinic is limited due to manufacturing challenges including the absence of an efficient and scalable platform purification process. Affinity chromatography has proven to be a viable solution for the purification of viral vectors but to date, a small number o  mostly single serotype-targeted affinity resins exist.

Download this whitepaper to learn how affinity chromatography can:

  • Purify multiple AAV subclasses with high binding efficiency
  • Reduce purification steps 
  • Maximize productivity