Sensitive DNA Methylation Detection Using Droplet Digital PCR
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DNA methylation plays a critical role in developmental and physiological processes, where aberrant methylation can lead to a variety of disease states including cancer.
Cell-free DNA (cfDNA) samples are used to detect methylation changes, but sensitive, robust and cost-effective analysis methods remain an unmet need.
This whitepaper demonstrates how common methylation detection methods can be combined with Droplet Digital PCR (ddPCR) to enhance the cfDNA analysis for clinical and research applications.
Download this whitepaper to learn more about:
- Critical parameters for ddPCR assay design
- The advantages of methylation detection using MSRE ddPCR
- Considerations for choosing a cytosine deamination method
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