How Organoids Are Fueling Infectious Disease Research and Personalized Medicine
In this article, we discuss organoids in the context of personalized medicine and infectious disease and explore how they provide a new window into disease and fuel the discovery of new therapeutics.
Western Blot Procedures, Analysis and Purpose
There are many reasons you may need to determine the presence (or absence) and size of a given protein within a sample, potentially against a background of many others. The western blot is one such technique that offers these capabilities. In this article, we discuss what western blots are, how they are performed, what they show us and how they differ to related techniques.
Immunity to Infection Passed On to Subsequent Generations
Does an infection also affect the immunization of subsequent generations? Mouse fathers who had previously overcome an infection with fungi or were stimulated with fungal compounds also passed on their improved protection to their offspring across several generations.
Protein Focuses Immune Attack on HIV-Infected Cells
Armed with a novel strategy they developed for bolstering the body’s immune response, scientists at Albert Einstein College of Medicine have successfully suppressed HIV infections in mice—offering a path to a functional cure for HIV and other chronic viral infections.
Vaccines Over 90% Protective Effective at Preventing Death From Delta Variant
Research has found that the Pfizer-BioNTech vaccine is 90% effective and the Oxford-AstraZeneca vaccine 91% effective in preventing deaths from the Delta variant of COVID-19.
Tests Developed in the Fight Against Environmental Spread of Antimicrobial Resistance
New PCR assays offer hope in the fight against the environmental spread of antimicrobial resistance. The method, which is similar to methods used on wastewater samples to detect SARS-CoV-2, differentiates between bacteria carrying AMR genes versus no AMR genes.
Monoclonal vs Polyclonal Antibodies
Antibodies are immunological proteins that play fundamental roles in host defense against infectious agents such as viruses, bacteria and fungi. Two types of antibodies – polyclonal and monoclonal – provide research scientists with distinct ways to detect or quantify target antigens largely due to differences in specificity and affinity. In this article, we describe polyclonal and monoclonal antibodies in more detail and consider how each type may be used for various applications.
Bioelectric Assay Identifies Potential COVID-19 Therapeutic Targets
Bioelectronic assays extend our ability to quickly study interactions between cells, viruses, and therapeutics in real time over days, in one plate, without interference by labels or tags. This article highlights how the effect of various therapeutics on the cell-killing behavior of SARS-CoV-2 was assessed using a bioelectronic assay.
A Note to the Vaccinated: Thank You and Be Reassured
Recent headlines sparked fear after discussing waning immunity to SARS-CoV-2 after vaccination. In this op-ed, immunologist Michael Kinch addresses the subject of the articles and explains why it is normal for antibody levels in the blood to wane over time.
How To Pipette Accurately
Download this guide to learn how to avoid instrument damage, volume inaccuracies and sample and reagent contamination.
Why Single Cell Sequencing?
Download this guide to learn more about analyzing gene and protein expression, performing comprehensive immune phenotyping, mapping regions of open chromatin and much more.
Three Advances in Alzheimer’s Disease Diagnostics
Download this listicle to explore three major advances in dementia diagnostics, including blood biomarker analysis, polygenic risk scoring and non-invasive techniques.
Antibodies in Neuroscience
Antibodies are invaluable tools in many areas of life science research, including neuroscience. Download this listicle to discover how antibodies are being applied to address key questions in the field, explore manufacturing approaches and learn how to choose the right antibodies for your research.
What Is New in Disease Biomarker Discovery?
Download this listicle to explore various biomarkers, technological advances driving biomarker research and integrative approaches in disease research.