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Latest App Notes & Case Studies

App Note / Case Study

Superior Characterization of Biotherapeutic Quality Attributes Using Electron Activated Dissociation

The multi-attribute method (MAM) is a powerful LC-MS method that overcomes this challenge by simultaneously monitoring and quantifying multiple PQAs in a single injection.
App Note / Case Study

Comparison of Different Methods To Isolate High Molecular Weight DNA From Bacteria

Find out how scientists determined which of five extraction methods was optimal for use in a long-read sequencing workflow by comparing the sample quality, sample size and sequencing results.
App Note / Case Study

Monitoring Intact Light Chain of Therapeutic mAbs in Human Serum Using HRAM LC-MS

Download this tech note to learn how mass spectrometry has gained substantial popularity for therapeutic mAb monitoring in clinical laboratories due to its great versatility to detect both tryptic peptides and intact light and heavy chains quantitatively.
App Note / Case Study

Workflow and Performance of a Multiplex Real-Time PCR In Vitro Diagnostic Test

Identifying a respiratory viral infection can be challenging with different families of viruses being indistinguishable during the acute phase of illness, despite the outcome and long-term prognosis of the infection being different. The ability to diagnose a respiratory virus at the initial stage of infection can result in more effective treatment for the patient.
App Note / Case Study

How To Switch to Optimal Activity-Based Cytokine Dosing

Download this app note to discover a method that facilitates optimal and reproducible conditions and thus reliable results, provides optimal activity-based cytokine dosing plus saves reagent.
App Note / Case Study

Histamine in Complex Biological Matrices: Application to Inflammation Studies

Histamine is a molecule that plays a major role in local immune responses, produced and released by basophils and mast cells as part of the inflammatory response to a foreign body.
App Note / Case Study

Accelerating Target Validation for Therapeutics With Engineered Cell Libraries

One approach to develop drugs for infectious diseases involves a comprehensive understanding of human-pathogen protein interactions, as targeting host proteins helps reduce the possibility of drug resistance by creating a more significant evolutionary barrier for the virus.
App Note / Case Study

Identifying Genetic Drivers of Innate Immunity Using Custom Targeted CRISPR Screens

Using genome-wide CRISPR knockout screens, followed by focused CRISPR screens, researchers at Boehringer Ingelheim probed the gene-phenotype relationship of human monocyte phagocytosis when the cells were challenged with Staphylococcus aureus.
App Note / Case Study

Conducting Research on Highly Pathogenic Viruses Using Virus Pseudotypes

The threat that emerging viruses pose to human health should not be underestimated. These viruses have acquired the ability to infect humans either due to interspecies transmission or naturally occurring changes in the viral genome.
App Note / Case Study

Discover the Freshness of Frozen PBMCs

PBMCs are routinely isolated and frozen down for experimental use, but what impact does cryopreservation have on these cells?
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