Latest Application Notes

Application Note
Whole Genome Sequencing of SARS-CoV-2 by Hybridization Capture Method
Hybridization capture-based target enrichment employs probes to select sequences of interest in a next generation sequencing (NGS) library.

Application Note
Best Pipetting Practices
Despite daily use in every life science laboratory, best pipetting practices are not as well-known as one might expect. Many users are self-taught and have never received formal pipetting training during their professional career.

Application Note
Novel Aggregation-Specific Fluorogen Monitors Prefibrillar Protein Aggregation by Fluorescence Polarization
Highly ordered protein aggregates, termed amyloid fibrils, are associated with a broad range of diseases, many of which are neurodegenerative for example Alzheimer’s and Parkinson’s. The transition from soluble, functional protein to insoluble amyloid fibril occurs via a complex process involving the initial generation of highly dynamic early stage aggregates or prefibrillar species.

Application Note
Achieve Highly Sensitive Viral Detection with the SARS-CoV-2 NGS Assay - RUO
Download this application focus to learn more about the solutions available to optimize the sensitivity of viral detection.

Application Note
Genomic DNA Extractions Compared With the Agilent Femto Pulse System
Large-insert libraries require specific quality conditions of the starting genomic DNA (gDNA) material for successful outcomes. Physical, enzymatic and chemical shearing of gDNA into smaller fragments can occur at many different points during extraction and handling of gDNA.

Application Note
Quantifying T Cell Response in 3D Tumor Spheroids Using Advanced Flow Cytometry Workflows
Discovery of novel immunotherapies that specifically target and enhance the T cell response against cancer is a rapidly expanding research area. Robust and relevant in vitro models for evaluation of these immunotherapies is essential throughout their development.

Application Note
Improved GPCR Engineering With Synthetic Site Saturation Variant Libraries
Download this app note to learn more about how saturation mutagenesis can be used to identify functional GPCR variants, why error-prone PCR results in low variant representation as well as the advantages of synthetic saturation mutagenesis libraries.

Application Note
Recent Developments in Covid Virology
COVID-19 is caused by the SARS-CoV-2 virus. While some patients have mild or asymptomatic illness, for others it can be fatal. Understanding the immune response to SARS-CoV-2 at a molecular level is useful for the development of effective vaccines, treatments and prognostic tests.

Application Note
Accurately Analyze Fluorescent Widefield Images
The specificity of fluorescence microscopy allows researchers to accurately observe and analyze biological processes and structures quickly and easily, even when using thick or large samples. However, out-of-focus fluorescence increases background, reduces contrast and makes accurate image segmentation more challenging.

Application Note
Pushing the Boundaries of High Sensitivity Epigenetic Applications
Download this free application focus to learn more about innovative next-generation methylation detection systems.
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