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Latest Application Notes

Whole Genome Sequencing of SARS-CoV-2 by Hybridization Capture Method
Application Note

Whole Genome Sequencing of SARS-CoV-2 by Hybridization Capture Method

Hybridization capture-based target enrichment employs probes to select sequences of interest in a next generation sequencing (NGS) library.
Best Pipetting Practices
Application Note

Best Pipetting Practices

Despite daily use in every life science laboratory, best pipetting practices are not as well-known as one might expect. Many users are self-taught and have never received formal pipetting training during their professional career.
Novel Aggregation-Specific Fluorogen Monitors Prefibrillar Protein Aggregation by Fluorescence Polarization
Application Note

Novel Aggregation-Specific Fluorogen Monitors Prefibrillar Protein Aggregation by Fluorescence Polarization

Highly ordered protein aggregates, termed amyloid fibrils, are associated with a broad range of diseases, many of which are neurodegenerative for example Alzheimer’s and Parkinson’s. The transition from soluble, functional protein to insoluble amyloid fibril occurs via a complex process involving the initial generation of highly dynamic early stage aggregates or prefibrillar species.
Achieve Highly Sensitive Viral Detection with the SARS-CoV-2 NGS Assay - RUO
Application Note

Achieve Highly Sensitive Viral Detection with the SARS-CoV-2 NGS Assay - RUO

Download this application focus to learn more about the solutions available to optimize the sensitivity of viral detection.
Genomic DNA Extractions Compared With the Agilent Femto Pulse System
Application Note

Genomic DNA Extractions Compared With the Agilent Femto Pulse System

Large-insert libraries require specific quality conditions of the starting genomic DNA (gDNA) material for successful outcomes. Physical, enzymatic and chemical shearing of gDNA into smaller fragments can occur at many different points during extraction and handling of gDNA.
Quantifying T Cell Response in 3D Tumor Spheroids Using Advanced Flow Cytometry Workflows
Application Note

Quantifying T Cell Response in 3D Tumor Spheroids Using Advanced Flow Cytometry Workflows

Discovery of novel immunotherapies that specifically target and enhance the T cell response against cancer is a rapidly expanding research area. Robust and relevant in vitro models for evaluation of these immunotherapies is essential throughout their development.
Improved GPCR Engineering With Synthetic Site Saturation Variant Libraries
Application Note

Improved GPCR Engineering With Synthetic Site Saturation Variant Libraries

Download this app note to learn more about how saturation mutagenesis can be used to identify functional GPCR variants, why error-prone PCR results in low variant representation as well as the advantages of synthetic saturation mutagenesis libraries.
Recent Developments in Covid Virology
Application Note

Recent Developments in Covid Virology

COVID-19 is caused by the SARS-CoV-2 virus. While some patients have mild or asymptomatic illness, for others it can be fatal. Understanding the immune response to SARS-CoV-2 at a molecular level is useful for the development of effective vaccines, treatments and prognostic tests.
Accurately Analyze Fluorescent Widefield Images
Application Note

Accurately Analyze Fluorescent Widefield Images

The specificity of fluorescence microscopy allows researchers to accurately observe and analyze biological processes and structures quickly and easily, even when using thick or large samples. However, out-of-focus fluorescence increases background, reduces contrast and makes accurate image segmentation more challenging.
Pushing the Boundaries of High Sensitivity Epigenetic Applications
Application Note

Pushing the Boundaries of High Sensitivity Epigenetic Applications

Download this free application focus to learn more about innovative next-generation methylation detection systems.
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