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Latest Application Notes

Application Note

Imaging Organoids With Light-Sheet Fluorescence Microscopy

Studying tissue and organ biology is challenging, particularly in mammals, given sample accessibility and ethical concerns. However, the use of organoids alleviates these challenges, supporting researchers in exploring questions that previously could not have been investigated without them.
Application Note

Accurate Quantification of Interferon Gamma Across Immunoassay Platforms

Download this app note to discover immunoassay platforms that are consistent for your cell therapy and immunology development needs.
Application Note

Spatially Resolved Heterogeneity of Triple Negative Breast Cancer

Triple negative breast cancer (TNBC) is unresponsive to traditional hormone or targeted therapies and highly heterogeneous. Improved understanding of the biological underpinnings and cell-type composition of TNBC is critical to developing novel targeted treatment options.
Application Note

LC-MS for Detection of SARS-CoV-2 Viral and Host Proteins

This technical note provides a comprehensive LC-MS proteomic analysis to detect and monitor COVID-19 infection severity and disease progression.
Application Note

Where Do We Go From Here: A Reflection of COVID-19

Download this app note to explore various solutions designed to improve COVID-19 detection and the development of vaccines and therapeutics.
Application Note

Studying the Molecular Mechanism of Viral Replication in Real Time

Download this app note to discover a fluorescent-based approach that can enable real-time measurement of viral gene expression and be used to study virtually any virus in a 96- or 384- well format.
Application Note

Enhancing the Therapeutic Properties of a Cancer-Targeting Affibody by Soft Mutagenesis

Affibodies are synthetic antigen-binding proteins. They offer many advantages over monoclonal antibodies, including smaller sizes, enhanced thermal stability and rapid refolding capability. These advantages make affibodies an attractive platform for the development of therapeutics, diagnostics and bioimaging technology.
Application Note

Tiling Across Viral Genomes to Investigate Immune Escape

Viruses exploit high-dimensional RNA structures to facilitate viral replication and impede host restriction. Here, a novel next-generation sequencing (NGS)-based screening workflow, called Fate-seq, was used to define and characterize high-dimensional RNA structures.
Application Note

Convenient Customization of Your Cation Exchange Analysis

Therapeutic monoclonal antibodies (mAbs) are highly heterogeneous molecules due to being composed of a large number of variants. When the variants are present in the pharmaceutical protein, it is possible their biological activity could be altered.
Application Note

Benefits of an Ergonomic and Electronic Pipette for RT-PCR

Pipetting ergonomics has emerged as an important consideration in the research laboratory, especially during the past year when diagnostic laboratories were forced to work for long hours due to the global SARS-CoV-2 pandemic.
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