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Application Notes

 
Aggregation Rate Generator Monitors Protein and Polymer Stability
Application Note

Fluence Analytics’ ARGEN platform continuously measures the light scattering from 16 independent solutions to assess the pharmaceutical stability of therapeutic proteins and natural polymers.

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Evaluation of the IntelliQube® for Gene Expression Analysis using a One-Step RT-PCR Workflow
Application Note

Douglas Scientific

A recent study demonstrates the ability of the IntelliQube® and associated Array Tape®, to process RNA samples using a one-step RT-PCR workflow, opening the door to a variety of RNA screening applications including gene expression or viral detection and quantification.

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ENRICHMENT AND PURIFICATION OF CD3+ T-CELLS FROM HUMAN UMBILICAL CORD BLOOD
Application Note

Quad Technologies’ has partnered with the University of Massachusetts Medical School (Worcester, MA, USA) to evaluate the performance of the MagCloudz™ Streptavidin cell separation kit.

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Contribution of variable domains to the stability of humanized IgG1 monoclonal antibodies
Application Note

Malvern Panalytical

The rapid growth of the therapeutic antibody market has increased the interest in modeling of the antibody structure and in understanding the factors that affect the function and the stability of antibodies.

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Engineering Monoclonal Antibodies to Enhance Drugability: A Case Study
Application Note

Malvern Panalytical

In this manuscript we compare the stability of three different engineered antibodies as determined by SEC-HPLC analysis during accelerated stability studies, with the stability predicted by DSC.

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Characterization of IgG Monomers & Their Aggregates
Application Note

Malvern Panalytical

In this application note we characterize two antibody samples using column calibration and multi-detection SEC.

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Understanding Antibody and Viral Glycoprotein Interactions Using CG-MALS
Application Note

WITec

We used size-exclusion chromatography coupled with multi-angle light scattering to determine the molar mass and native oligo-meric state of a viral glycoprotein.

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Charge and Interaction Analysis for Predicting Antibody Formulation Stability
Application Note

WITec

Colloidal stability is a key solution property of a biotherapeutic formulations, indicative of long-term stability. As it is readily measured over much shorter time scales than long-term stability testing or even accelerated testing regimens, measurements of colloidal stability are often utilized in the course of formulation work to screen out poorly behaved conditions.

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Performing ADCC Reporter Bioassay with an Environmentally Controlled Microplate Reader
Application Note

Tecan Group Ltd.

The Promega ADCC Reporter Bioassay provides effector and target cells in frozen, thaw-and-use format, removing the need for isolating or culturing cells in order to perform the assay. Reporter induction requires a six-hour to overnight incubation in a standard cell culture incubator. The CO2 and temperature control features of the Tecan Infinite® 200 PRO with GCM allow the assay induction to be performed without the requirement for a cell culture incubator.

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Tag-lite® two-cell assay: a valuable tool for protein drug discovery
Application Note

Tecan Group Ltd.

Antibodies are central mediators of the immune system, IgG being the most dominant. Binding of IgG/antigen complexes to membrane-bound Fc? receptors triggers a cellular immune response. Alterations in the Fc portion of the antibody by introducing mutations can lead to complete abolition of Fc? receptor binding. This describes the development of a cellbased TR-FRET assay to determine the simultaneous binding of an antibody to its antigen and huFc?RIIIa present on different cells.

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