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Mannose Glycans Content Screening for Human-mAb Samples

Mannose Glycans Content Screening for Human-mAb Samples content piece image

Glycosylation refers to the formation of linkages with glycosyl groups, covalently attaching a carbohydrate to another molecule. Antibody glycosylation is critical due to the role carbohydrates play in modulating effector functions which affect safety and efficacy of therapeutic antibodies. Current glycan detection methods are plagued with high propensity for non-specific binding making them less reliable as tools.

Download this app note to discover a kit that:

  • Correlates well with HPLC and MS techniques
  • Does not require sample purification or enzymatic digestion prior to analysis
  • Facilitates the selection of optimal clones during cell line development