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Enhancement of Sensitive Bioanalysis of Biomarkers in Cerebral Spinal Fluid

Sensitive Bioanalysis of Biomarkers in Cerebral Spinal Fluid
Credit: iStock

The analysis of cerebral spinal fluid (CSF) is extremely valuable for diagnosing neurological disorders and diseases.

CSF is the is the closest matrix available to monitor changes in the brain; however, the volume available is extremely limited as several biomarker assays typically need to be performed on a single sample.

This app note highlights the use of HILIC-MS to detect two biomarkers for diseases such as Krabbe and Gaucher disease in lower volumes of CSF.

Download this app note to discover a system that: 

  • Enhances the sensitivity of biomarker analysis in CSF 
  • Demonstrates good accuracy and linearity
  • Shows improved signal/noise ratios compared to older systems
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