Developing Novel Cell Therapies by Rewiring T-Cell Genomes
In a recent Teach Me in 10 episode, Dr. Theo Roth discussed what targeted pooled knock-in screens are, how he is working to accelerate the discovery of cell-based therapies and how this process could reduce the time it takes to transition these therapies from the lab to the clinic.
Immunohistochemistry Techniques, Strengths, Limitations and Applications
Immunohistochemistry exploits antigen–antibody binding to study the status of target molecules in tissues of interest. In this article, we explore how it works, factors that impact experimental design and its applications.
An Introduction to Electroporation – A Tool for Transfection and Competent Cell Generation
There are many reasons you may want to deliver something into a cell, be it genetic material or a therapeutic drug, and electroporation is a vital tool to achieve this. In this article, we will consider what electroporation is, how it works and how it’s used.
Mapping the Body’s Defense System: The Immune Cell Atlas
This article will provide an introduction to the Immune Cell Atlas, highlight some of the research contributing to the project and explore the wider implications of the work.
Data Sharing Initiative Could Improve Our Understanding and Help To Reduce Antimicrobial Resistance
Antimicrobial resistance is a looming global threat for which we need a better understanding to tackle. We hear how a non-profit organization are helping scientists share valuable data effectively with the launch of the AMR register.
Emerging Technological Landscapes in Biomanufacturing and Monoclonal Antibody Screening
This article aims to understand the current challenges in biomanufacturing and screening mAb profiles, and how innovative tools allow for greater insight when monitoring the critical attributes of mAbs.
Drugs, Vaccines and a Hopeful Future: Exploring Advances in Multiple Sclerosis Research
World Multiple Sclerosis (MS) Day recognizes the millions of people worldwide who are affected by this neuroimmunological disease. The campaign site for World MS Day 2022 strikes an optimistic chord, seeing the date as a chance to “celebrate global solidarity and hope for the future”. This year, there is more reason to buy into that optimism than ever before.
Why Ever More Boosters Could Hurt More Than Help
In this opinion article, Michael S Kinch explains why the calls for additional booster shots to combat the COVID-19 pandemic is, from his perspective, increasingly troubling.
Rewiring T Cells To Enhance Immunotherapy Efficacy
Researchers have identified a modifier gene called lymphotoxin beta receptor (LTBR) – which is not normally expressed in T cells – and combined it with CARs to create T cells that were better equipped at killing tumor cells.
Re-Educating the Immune Response To Treat Type 1 Diabetes
CAR T-cell therapy is largely used to treat cancers, but here we explore how Dr. Leonardo Ferreira and his team are using CAR T-cell therapy to treat Type 1 diabetes.