Controlling cell migration

Latest research

1. 1. Microbiology and Infectious Disease
   2. Structural Biology and Molecular Biophysics

   Molecular mechanism of complement inhibition by the trypanosome receptor ISG65

   Alexander D Cook, Mark Carrington, Matthew K Higgins

   A structure derived from cryogenic electron microscopy shows how ISG65, an African trypanosome receptor that aids virulence, binds C3b and suggests mechanisms through which ISG65 might aid complement resistance.
2. 1. Chromosomes and Gene Expression
   2. Immunology and Inflammation

   Foxp3 depends on Ikaros for control of regulatory T cell gene expression and function

   Rajan M Thomas, Matthew C Pahl ... Andrew D Wells

   Foxp3 and Ikaros, two transcription factors genetically linked to autoimmune disease in humans, cooperate to establish the epigenomic and transcriptomic landscape of regulatory T cells.
3. 1. Cell Biology
   2. Structural Biology and Molecular Biophysics

   PURA syndrome-causing mutations impair PUR-domain integrity and affect P-body association

   Marcel Proske, Robert Janowski ... Dierk Niessing

   Structural promiscuity in PURA protein, induced by patient mutations, impacts nucleic acid binding, unwinding, and subcellular localization, indicating why so many patients display the full disease spectrum of PURA syndrome.
4. 1. Neuroscience

   Regional response to light illuminance across the human hypothalamus

   Islay Campbell, Roya Sharifpour ... Gilles Vandewalle
5. 1. Ecology

   Coordinated molecular and ecological adaptations underlie a highly successful parasitoid

   Lan Pang, Gangqi Fang ... Jianhua Huang
6. 1. Biochemistry and Chemical Biology

   A multi-hierarchical approach reveals d-serine as a hidden substrate of sodium-coupled monocarboxylate transporters

   Pattama Wiriyasermkul, Satomi Moriyama ... Shushi Nagamori

   An unbiased approach unveils a non-canonical substrate of the known transporters, highlighting the mechanism behind the use of D-serine as a kidney biomarker.
7. 1. Developmental Biology

   Inhibitory G proteins play multiple roles to polarize sensory hair cell morphogenesis

   Amandine Jarysta, Abigail LD Tadenev ... Basile Tarchini

   Sensory hair cells in the inner ear use inhibitory G proteins with different regulators at different stages of development to break symmetry, adopt a proper orientation, and grow stereocilia.
8. 1. Structural Biology and Molecular Biophysics

   LRMP inhibits cAMP potentiation of HCN4 channels by disrupting intramolecular signal transduction

   Colin H Peters, Rohit K Singh ... John R Bankston

   A combination of patch clamp electrophysiology and FRET determine critical interactions between HCN4 channels and the ER resident protein LRMP and suggest a possible mechanism for reduced cAMP sensitivity.
9. 1. Cancer Biology

   Recording and classifying MET receptor mutations in cancers

   Célia Guérin, David Tulasne

   Classification of MET mutations allows a better understanding of sensitivity and resistance to targeted therapies used in cancer.
10. 1. Computational and Systems Biology
    2. Developmental Biology

    A logic-incorporated gene regulatory network deciphers principles in cell fate decisions

    Gang Xue, Xiaoyi Zhang ... Zhiyuan Li

    A top-down model-guided framework unveils the role of regulatory logics underlying gene regulatory networks in cell fate decisions.