CD47: Regulation of cellular phagocytosis in cancer, inflammation & neurobiology
Infographic Oct 11, 2017
CD47 is a cell surface ‘don’t eat me’ signal that has been shown to be important in detection and evasion of cancer cells, inflammation, neuronal pruning and other pathophysiological processes.
Blocking CD47 allows tumor cells to be recognized by phagocytes and this cell-cell interaction initiates a cascade of events resulting in tumor cell destruction. As such CD47 is an attractive target for the development of novel therapeutics.
Download this Infographic for an overview of the dynamics of CD47 signaling in the regulation of cancer, inflammation and neuronal pruning and methods to target this pathway for potential immunotherapies.
The extent to which resident microbes can affect our health is slowly being realized, and our current understanding may be just the tip of the iceberg. Download this infographic to learn how knowledge of the microbiome can be used to aid medical decision-making, as well as current trends, goals, techniques and challenges of the field.READ MORE