CD47: Regulation of cellular phagocytosis in cancer, inflammation & neurobiology
Infographic Oct 11, 2017
CD47 is a cell surface ‘don’t eat me’ signal that has been shown to be important in detection and evasion of cancer cells, inflammation, neuronal pruning and other pathophysiological processes.
Blocking CD47 allows tumor cells to be recognized by phagocytes and this cell-cell interaction initiates a cascade of events resulting in tumor cell destruction. As such CD47 is an attractive target for the development of novel therapeutics.
Download this Infographic for an overview of the dynamics of CD47 signaling in the regulation of cancer, inflammation and neuronal pruning and methods to target this pathway for potential immunotherapies.
The idea that a person’s immune system can fight cancerous cells was conceived over 100 years ago. Nobel prize-winning German physician and scientist, Paul Ehrlich suggested that the incidence of cancer would be significantly higher if it wasn’t for our immune system – bringing to light immune cells’ incredible ability to recognize, target, seek out, and destroy cancerous cells.READ MORE