Host Cell Protein Analysis in 2020
Listicle Aug 13, 2020 | By Michele Wilson, PhD
During biotherapeutic production, a range of impurities and variants can be generated, including host cell proteins (HCPs). HCPs present a safety risk as they can produce immunogenic responses and may reduce drug efficacy. To meet regulatory criteria, developers must verify that HCPs have been reduced to an acceptable level.
To keep up with the rapidly growing biotherapeutic industry, the large analytical toolkit of techniques for HCP analysis has continued to evolve.
Download this listicle to discover five recent approaches which help to improve the separation and detection of HCPs, using technologies such as:
- One-dimensional liquid chromatography
- Advanced biosensors
- Host cell line engineering
As biology presents ever-more challenging targets, those in the drug discovery field are pushing ahead with new tools to design or discover drugs that have optimal kinetics. But how familiar are you with the key terms used by scientists performing kinetics-directed drug design and discovery? Here, we have compiled a list of key definitions for your reference.READ MORE