We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
Antibacterial Amino Acid Derivatives of Schiff Base Copper Complexes Made in Under 10 Minutes
News

Antibacterial Amino Acid Derivatives of Schiff Base Copper Complexes Made in Under 10 Minutes

Antibacterial Amino Acid Derivatives of Schiff Base Copper Complexes Made in Under 10 Minutes
News

Antibacterial Amino Acid Derivatives of Schiff Base Copper Complexes Made in Under 10 Minutes

Researchers from Tokyo University of Science employed a two-step microwave irradiation technique to synthesize amino acid Schiff base Cu (II) complexes within 10 minutes. The prepared bases exhibited light antioxidant properties and antibacterial activity toward E. coli. Credit: IRRI on Creative Commons
Read time:
 

Want a FREE PDF version of This News Story?

Complete the form below and we will email you a PDF version of "Antibacterial Amino Acid Derivatives of Schiff Base Copper Complexes Made in Under 10 Minutes"

First Name*
Last Name*
Email Address*
Country*
Company Type*
Job Function*
Would you like to receive further email communication from Technology Networks?

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

Ever since their development in the late 19th century, Schiff bases have been a popular group of organic compounds, owing to their wide variety of desirable properties. The presence of both nitrogen and oxygen in their structure makes them versatile molecules with an array of applications, ranging from dyes and catalysts to environmental sensors and raw materials for chemical synthesis.


Recently, there has been growing interest in the biological activity of Schiff bases, as researchers have discovered that metal complex derivatives of Schiff bases can serve as antioxidant, antimicrobial, and anticancer agents. Among these compounds, studies have shown that amino acid Schiff base copper (Cu) complexes have the most promising antimicrobial properties; however, the reaction time taken to create these compounds can range from hours to days.


In a recent breakthrough published on 18 June 2022 in Applied Microbiologya team of researchers led by Professor Takashiro Akitsu from the Tokyo University of Science reported a two-step synthesis procedure that produced amino acid Schiff base Cu (II) complexes within a mere 10 minutes! The team included Dr. Estelle Léonard and Dr. Antoine Fayeulle from ESCOM, TIMR (Integrated Transformations of Renewable Matter), Centre de Recherche Royallieu, University of Technology of Compiègne, France.


“Amino acid Schiff base Cu (II) complexes have the potential to be used as antimicrobial agents but their wider applications are being limited by conventional methods for synthesis that often takes several hours and sometimes days. With our research, we aim to overcome this challenge by making the synthesis process more facile,” comments Prof. Akitsu on the rationale behind their study.


The team used microwave irradiation to prepare these compounds, owing to its ability to greatly accelerate the reaction while providing controlled heating. This method also ensures higher yields, better purity, and fewer by-products. Additionally, they chose methanol as the solvent for the reactions. With a high loss tangent of 0.659, which determines the ability to convert microwave energy into heat, and a high microwave absorption rate, methanol was ideal for accelerating the reactions and lowered the global reaction time to 10 minutes.


To gauge the antibacterial properties of the compounds, the researchers tested them against various bacteria. They found that the one- and two-chlorine substituted complexes showed better action against bacteria, with remarkable activity against E. coli, than the molecules with no chlorine groups. The team also noted the presence of light antioxidant properties in the one- and two-chlorinated complexes. In the future, the team aims to check for the toxicity of these compounds toward kidney, liver, and skin cells.


This new synthesis technique minimizes the global reaction time, maximizes the reaction conditions, and produces high purity products with promising antibacterial activity. The insights from this study can be used as a framework for the development of fast and facile synthesis techniques for biologically active amino acid derivatives of Schiff base metal complexes. “Bacterial infectious diseases are a major threat to public health. Our study aims to contribute towards the improvement of health care systems in developing nations that are often affected by infectious epidemics,” concludes Prof Akitsu.


Reference: Otani N, Fayeulle A, Nakane D, Léonard E, Akitsu T. Synthesis, identification and antibacterial activities of amino acid Schiff base Cu(II) complexes with chlorinated aromatic moieties. Appl Microbiol. 2022;2(2):438-448. doi: 10.3390/applmicrobiol2020032

 

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

 

Advertisement