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Discovery Made On How To Reduce Severe Tissue Damage From Some Viral Infections

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McMaster University researchers have found not only how some viral infections cause severe tissue damage, but also how to reduce it.

They have discovered how Type I interferon (IFN) stops the immune system from ‘going rogue’ and attacking the body’s own tissues when fighting viral infections, including COVID-19.

Their paper was published in the journal PLOS Pathogens on May 17.

Senior author Ali Ashkar said IFN is a well-known anti-viral signalling molecule released by the body’s cells that can trigger a powerful immune response against harmful viruses.

“What we have found is that it is also critical to stop white blood cells from releasing protease enzymes, which can damage organ tissue. It has this unique dual function to kick start an immune response against a viral infection on the one hand, as well as restrain that same response to prevent significant bystander tissue damage on the other,” said Ashkar, a professor of medicine at McMaster.

The research team investigated IFN’s ability to regulate a potentially dangerous immune response by testing it on both flu and the HSV-2 virus, a highly prevalent sexually transmitted pathogen, using mice. Data from COVID-19 patients in Germany, including post-mortem lung samples, was also used in the study.

“For many viral infections, it is not actually the virus that causes most of the tissue damage, it is our heightened immune activation towards the virus,” said Ashkar.

First co-author of the study and PhD student Emily Feng said: “Our body’s immune response is trying to fight off the virus infection, but there’s a risk of damaging innocent healthy tissue in the process. IFN regulates the immune response to only target tissues that are infected.”

“By discovering the mechanisms the immune system uses that can inadvertently cause tissue damage, we can intervene during infection to prevent this damage and not necessarily have to wait until vaccines are developed to develop life-saving treatments,” she said.

First study co-author Amanda Lee, a family medicine resident said: “This applies not just to COVID-19, but also other highly infectious viruses such as flu and Ebola, which can cause tremendous and often life-threatening damage to the body’s organs.”

“This has the potential in the future to be used to alleviate virus-induced life-threatening inflammation and warrants further research.”

Ashkar said the release of harmful proteases is the result of a ‘cytokine storm,’ which is life-threatening inflammation sometimes triggered by viral infections. It has been a common cause of death in patients with COVID-19, but treatment has been developed to prevent and suppress the cytokine storm.

Ashkar said that steroids like dexamethasone are already used to rein in an extreme immune response to viral infections. The authors used doxycycline in their study, an antibiotic used for bacterial infections and as an anti-inflammatory agent, to inhibit the function of proteases causing the bystander tissue damage.

Reference: Lee AJ, Feng E, Chew MV, et al. Type I interferon regulates proteolysis by macrophages to prevent immunopathology following viral infection. PLOS Path. 2022;18(5):e1010471. doi:10.1371/journal.ppat.1010471

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