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First-of-Its-Kind Atlas Maps Complexities of Autoimmune Disease

News   Apr 30, 2021 | Original story from University of Tokyo

 
First-of-Its-Kind Atlas Maps Complexities of Autoimmune Disease

Each person only has one genome, but different parts of the genome are active in different cell types. In the example above, a region of regulatory DNA (blue star) is active only in Cell A. This regulatory DNA controls expression level of Gene Y. Different people have different variations of that regulatory DNA sequence (AA, AG or GG genetic polymorphisms), which lead to different expression levels of Gene Y (top right red graph). This type of data was used to build the ImmuNexUT database, which will allow experts to understand how DNA sequence differences lead to changes in gene expression and cause different immune system diseases. Credit: Diagram by Mineto Ota, Creative Commons By Attribution 4.0

 
 
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