We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
Homing in on Macrophage's Role for "Seeds"
News

Homing in on Macrophage's Role for "Seeds"

Homing in on Macrophage's Role for "Seeds"
News

Homing in on Macrophage's Role for "Seeds"

Credit: Pixabay.
Read time:
 

Want a FREE PDF version of This News Story?

Complete the form below and we will email you a PDF version of "Homing in on Macrophage's Role for "Seeds""

First Name*
Last Name*
Email Address*
Country*
Company Type*
Job Function*
Would you like to receive further email communication from Technology Networks?

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

Hematopoietic Stem and Progenitor Cells (HSPCs) give rise to all blood lineages that support people’s life. HSPCs, like seeds, need a suitable microenvironment to maintain their function.

A process called “homing” allows HSPCs to anchor in their niches in order to expand and differentiate. Unique niche microenvironments, composed of various blood vessels and other niche components, including stromal cells, regulate this process.


To study the detailed architecture of the microenvironment and the regulation mechanism of homing, Prof. PAN Weijun’s group at the Shanghai Institute of Nutrition and Health of Chinese Academy of Sciences used a zebrafish model to analyze the entire dynamic process of HSPC homing in vivo. The results entitled “VCAM-1+ macrophages guide the homing of HSPCs to a vascular niche” was published in Nature on Nov. 19, 2018.


By using a combination of advanced live imaging and a cell labeling-tracing system, researchers performed a high-resolution analysis of HSPC homing in zebrafish caudal hematopoietic tissue (CHT, equivalent to the fetal liver in mammals).


Compared to itga4 mutants with homing defects, successful HSPC retention was defined in CHT as the lodgement of HSPCs for more than 30 minutes.


The researchers also found that HSPCs preferred to stay at retention “hotspots” associated with venous capillaries, which are largely localized at the venous capillary confluence points connected to the caudal vein plexus.


Further study showed that VCAM-1+ macrophages patrolling the inner surface of the venous plexus interact with HSPCs in an ITGA4-dependent manner and direct HSPC retention.


These cells, named “usher cells,” guide HSCP homing to two types of vascular niches. Usher cells, together with endothelial cells, help HSPC homing through distinct mechanisms.


This study dissects the temporal-spatial rules of HSPC retention, provides new insights into the mechanism for HSPC homing, and reveals the essential role of a VCAM-1+ macrophage population with patrolling behavior in HSPC retention.


The study was funded by grants from the Chinese Academy of Sciences, the Ministry of Science and Technology, and the National Natural Science Foundation of China, among others.

This article has been republished from materials provided by the Chinese Academy of Sciences. Note: material may have been edited for length and content. For further information, please contact the cited source.

Reference
VCAM-1+ macrophages guide the homing of HSPCs to a vascular niche. Dantong Li, Wenzhi Xue, Mei Li, Mei Dong, Jianwei Wang, Xianda Wang, Xiyue Li, Kai Chen, Wenjuan Zhang, Shuang Wu, Yingqi Zhang, Lei Gao, Yujie Chen, Jianfeng Chen, Bo O. Zhou, Yi Zhou, Xuebiao Yao, Lin Li, Dianqing Wu & Weijun Pan. Nature (2018), https://doi.org/10.1038/s41586-018-0709-7.

Advertisement