We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
Immune Cell Acts as Shuttle To Spread HIV Around the Body
News

Immune Cell Acts as Shuttle To Spread HIV Around the Body

Immune Cell Acts as Shuttle To Spread HIV Around the Body
News

Immune Cell Acts as Shuttle To Spread HIV Around the Body

Credit: John Kehrl and Chung Park
Read time:
 

Want a FREE PDF version of This News Story?

Complete the form below and we will email you a PDF version of "Immune Cell Acts as Shuttle To Spread HIV Around the Body"

First Name*
Last Name*
Email Address*
Country*
Company Type*
Job Function*
Would you like to receive further email communication from Technology Networks?

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

New insight on how a type of cell facilitates the spread of HIV-1 in mice suggests that subcapsular sinus macrophages, the first layer of cells in the draining lymph node, act as a kind of “shuttle” for HIV-1 virus-like particles. These cells help the particles spread by loading them onto two types of immune cells, follicular dendritic cells and B cells.

HIV is a virus that damages immune cells and suppresses the host’s ability to fight everyday infections and disease. During HIV-1 infection, follicular dendritic cells act as a reservoir for the virus and an obstacle to curative treatments, but it was not well known how these cells initially acquire and preserve HIV-1.

Researchers from the National Institute of Allergy and Infectious Diseases (NIAID), part of the U.S. National Institutes of Health in Bethesda, Maryland, set out to investigate this further. The team consisted of John Kehrl, Chief of the B-cell Molecular Immunology Section of NIAID, and Chung Park, Staff Scientist in the same department.

In their study, Kehrl and Park visualized the likely early events in the spread of HIV-1 virus-like particles in mice. They looked at how the virus moves from the lymph and blood via sinus-lining macrophages, and how it is then transferred to underlying networks of follicular dendritic cells.

Their work highlighted a subset of lymphoid organ sinus-lining macrophages that provide a cell-to-cell contact portal to shuttle HIV-1 particles onto follicular dendritic and B cells in the lymph node and spleen. They found that a type of protein called MFG-E8 is central to the proper function of this portal, as its absence severely limited the spread of HIV-1 onto follicular dendritic cell networks.

“The team also revealed that the HIV-1 envelope, which encloses the viral particle and helps the virus enter cells, provides a means for MFG-E8 binding. MFG-E8 acts to link the HIV-1 particles to αvβ3 integrins expressed on the host’s cells. These integrins help the cell’s uptake of the viral particles, making the particles available to other cell types or, in some instances, targeting them for destruction. Kehrl and Park say that further work is now needed to see whether this process involving MFG-E8 works to benefit the host or the virus.”

Reference

Park and Kehrl. (2019) An Integrin/MFG-E8 shuttle loads HIV-1 viral like particles onto follicular dendritic cells in mouse lymph node. eLIFE. DOI: https://doi.org/10.7554/eLife.47776

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

Advertisement