We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.


Immune System Surprise Hints at New Strategy for Fighting HIV

Want a FREE PDF version of This News Story?

Complete the form below and we will email you a PDF version of "Immune System Surprise Hints at New Strategy for Fighting HIV"

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

Read time:

The discovery of the innate immunity system’s role in mobilizing the body’s defenses against invading microorganisms has been long studied at Yale. Now in the Nov. 17 issue of the journal Nature Immunology, Yale researchers led by Margarita Dominguez-Villar and David Hafler have discovered a surprising twist to the story that may open a new avenue in the fight against HIV.

An immune system response to microbial invaders is triggered when a family of receptors found in immune cells called Toll-like receptors are activated by invaders.

To the surprise of the Yale team, the researchers found that when a Toll-like receptor inside the CD4 immune cells, which are regularly destroyed by HIV, are blocked, it actually depresses — not activates — an immune system reaction.

Researchers now want to investigate whether manipulating this receptor could combat HIV infection.