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Key Dynamics of Immune Linchpin MHC Class I Revealed

News   Dec 04, 2019 | Original story from the University of California - Santa Cruz.

 
Key Dynamics of Immune Linchpin MHC Class I Revealed

In this schematic of peptide loading on class-I MHC proteins, the molecular chaperone TAPBPR (blue) catalyzes the loading of a small peptide antigen (purple), derived from a viral or tumor protein, on the peptide-binding groove of a class-I MHC protein (gray/green). The interplay between a highly polymorphic set of MHC-I alleles and molecular chaperones shapes the repertoire of peptide antigens displayed on the cell surface for T-cell surveillance. Credit: Andrew McShan.

 
 
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