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Norovirus More Resilient Than Previously Thought
News

Norovirus More Resilient Than Previously Thought

Norovirus More Resilient Than Previously Thought
News

Norovirus More Resilient Than Previously Thought

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Clusters of a virus known to cause stomach flu are resistant to detergent and ultraviolet disinfection, according to new research co-led by Danmeng Shuai, Ph.D., an associate professor of civil and environmental engineering at the George Washington University and Nihal Altan-Bonnet, Ph.D., a senior investigator and the head of the Laboratory of Host-Pathogen Dynamics at the National Heart, Lung, and Blood Institute, part of the National Institutes of Health. The findings suggest the need to revisit current disinfection, sanitation and hygiene practices aimed at protecting people from noroviruses.

Noroviruses are the leading cause of gastroenteritis around the world, with over 21 million cases each year in the United States alone.


In 2018, Altan-Bonnet's team found that noroviruses can be transmitted to humans via membrane-enclosed packets that contain more than one virus. In the past, scientists thought that viruses spread through exposure to individual virus particles, but the 2018 study--and others--showed how membrane-enclosed clusters arrive at a human cell and release an army of viruses all at once.


For the new study, Shuai, Altan-Bonnet and the study's first author Mengyang Zhang, a doctoral student co-advised through a GW/NIH Graduate Partnerships Program, looked at the behavior of these protected virus clusters in the environment. They found that the virus clusters could survive attempts to disinfect with detergent solutions or even UV light. Water treatment plants use UV light to kill noroviruses and other pathogens.


"These membrane-cloaked viruses are tricky," Shuai said. "Past research shows they can evade the body's immune system and that they are highly infectious. Our study shows these membrane enclosed viruses are also able to dodge efforts to kill them with standard disinfectants."


Altan-Bonnet added, "We have to consider these viral clusters cloaked in vesicle membranes as unique infectious agents in the public health arena. When it comes to virulence -- and now with this study, disinfection and sanitation -- the sum is much more than its parts. And these clusters are endowed with properties that are absent from other types of viral particles."


According to the researchers, future studies must be done to find out if certain kinds of cleaning solutions or higher dosages of UV light would degrade the protective membrane and/or kill the viruses inside. Ultimately, the research could be used to devise more effective disinfection methods that could be used to clean surfaces at home, in restaurants and in places where norovirus can spread and cause outbreaks, like cruise ships.


"Our study's findings represent a step towards recommendations for pathogen control in the environment, and public health protection," Altan-Bonnet said.

Reference
Zhang M, Ghosh S, Kumar M, et al. Emerging Pathogenic Unit of Vesicle-Cloaked Murine Norovirus Clusters is Resistant to Environmental Stresses and UV254 Disinfection. Environ Sci Technol. Published online April 15, 2021. doi:10.1021/acs.est.1c01763



This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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