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Revealing How C. diff Recognises its Human Target

News   May 14, 2018 | Original Story from the University of California - Irvine.

 
Revealing How C. diff Recognises its Human Target

The 3-D structure shows how a key C. diff toxin, TcdB (in orange), recognizes the human Frizzled protein (in green) as its receptor to invade cells, leading to damage in the intestinal barrier. Shown in the background is immunofluorescent staining of the healthy mouse cecum tissue (left) and the one damaged by TcdB (right). Credit: Rongsheng Jin.

 
 
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