Scientists Uncover New Role for Neurotransmitter that Helps Fight Infection
News Feb 25, 2015
The body has two types of immune response which work together: an innate response, which is the body’s immediate way of tackling infections, and an adaptive response.
The adaptive immune system is developed largely to combat secondary infections: having recognized an invading pathogen it will produce antibodies that can attack the infection. Other responses can also be triggered, such as mucus production to trap and expel pathogens.
Researchers at Imperial College London have shown that one particular type of neurotransmitter, or signalling molecule, has an important role in our adaptive immune response as well as in the innate immune system. If this signalling molecule could be mimicked and incorporated into a drug formulation, it could potentially be used to boost people’s immunity to infection.
The neurotransmitter, called acetylcholine, has a number of complex roles within the body. It helps to carry messages around the body’s nervous system to activate muscles, for example, while in the brain it is responsible for transmitting sensory information.
Acetylcholine is already known to also play a role in regulating the body’s innate immune response - for example, it can slow the inflammatory response to infection which, if unchecked, can lead to inflammatory diseases or organ damage.
In a study published in the journal PLOS Pathogens, a team from Imperial College London and the University of Cape Town showed that acetylcholine was also important for the production of cytokines - proteins which stimulate the body’s adaptive immune responses.
"We started to look at these neurotransmitters in relation to the adaptive immune response because of work that we had been doing on helminth parasites,” explained Professor Murray Selkirk, Head of the Department of Life Sciences at Imperial College London. “These parasitic worms have sophisticated ways of suppressing the immune system of their host. They release an enzyme that degrades acetylcholine. We suspected that this must be benefitting them in some way, suggesting that the neurotransmitter is doing something which is detrimental to the parasite."
In a collaboration with scientists at the University of Cape Town, the team studied a group of mice bred to be unresponsive to acetylcholine acting on a specific receptor. Some of the mice were infected with helminth parasites and some with salmonella bacteria, and their adaptive immune responses were measured. They discovered that the mice were less able to fight off either infection effectively, indicating that the neurotransmitter had a role to play in adaptive immunity.
“We already knew that this neurotransmitter played an important role in the innate immune system, but what we have found in this study is that it also activates other responses that are important for adaptive immunity,” says Professor Selkirk. “We hope this finding could lead to new ways of boosting people’s ability to fight off infection.”
The results are also significant for the use of existing drugs such as Tiotropium, which is used to treat chronic obstructive pulmonary disease, and recently approved for treatment of asthma.
These drugs work by inhibiting the neurotransmitter’s signalling system to impede smooth muscle contraction and mucus production - both of which worsen the symptoms of these diseases. This study suggests that in suppressing these, there could also be an effect on other immune responses, which now need to be investigated.
H7N9 Influenza Vaccine Clinical Trials CommenceNews
Two new clinical trials testing an experimental vaccine to prevent influenza caused by an H7N9 influenza virus are now enrolling volunteers at sites across the United States. The Phase 2 studies will test different dosages of the inactivated influenza vaccine candidate as well as different vaccination schedules. The studies also will evaluate whether an adjuvant boosts the immune responses of people receiving the vaccine.
Study Extends Potential of Personalized Cell-based ImmunotherapiesNews
New methods developed for the study could be applied to devise personalized, cell-based immunotherapies for epithelial ovarian cancer or other types of tumorsREAD MORE
Alternative to Antibiotics: Antibody Approach for Treating Multidrug-Resistant Bacterial InfectionsNews
Researchers are developing a promising alternative to antibiotic treatment for infections caused by Klebsiella pneumoniae bacteria resistant to carbapenem antibiotics. The approach uses antibodies to target the K. pneumoniae protective capsule polysaccharide.READ MORE
Comments | 0 ADD COMMENT
7th International Conference on Bacteriology and Infectious Diseases
Jun 04 - Jun 05, 2018