Seashells to Deliver New Drugs and Vaccines
News Jun 17, 2015
Published in the journal Nature Communications, the development overcomes a critical challenge in biomedicine by ensuring important proteins remain effective in hostile environments.
The new shell developed by CSIRO, The University of Adelaide and the Australian Synchrotron, could hold the key to cost-effectively preserving and extending the shelf-life of vaccines in extreme temperatures without refrigeration.
This could significantly benefit healthcare in developing countries where life-saving vaccines often need to be transported over long distances to reach everyone who needs them.
“Like a house is made of bricks, living organisms are made up of proteins which play a critical role in the body,” CSIRO lead researcher Dr Kang Liang said.
“But unlike bricks, proteins are fragile and their function alters or perishes when exposed to heat, pressure and pollutants.
“Inspired by a sea urchin’s outer shell, which supports and protects its fragile body, we’ve come up with a porous shell that grows around important proteins such as enzymes to protect them on the inside.
“Our shell offers a low-cost solution to protecting proteins for making and enhancing drugs and other products where sensitivity has long been an issue.”
The shell is made of an extremely porous material called metal organic frameworks (MOFs) that has a flexible and customisable cage-like structure.
“The shell’s tiny cage holes are similar to a sea creature’s pores and are designed to capture, trap or release specific biomolecules,” Dr Liang said.
It also paves the way to making new and improved consumer products. For example, shell-encapsulated enzymes in laundry washing powder would perform better, resulting in cleaner, softer and more fragrant clothing in less time.
CSIRO research team leader, Dr Paolo Falcaro said they are now seeking industry partners to develop the technology for specific applications including pharmaceuticals, manufacturing, chemical and food processing, water decontamination and screening for genetic disease.
“We are currently investigating important biomolecules including DNA, antibodies and those used in vaccines,” Dr Falcaro said.
“Based on our laboratory trials, the shell could protect a vaccine vial for only a few dollars and at a commercial scale we would work to make it even cheaper. This cost is insignificant when a vaccine can cost up to hundreds of dollars per dose.”
CSIRO is developing a range of technologies for making and using MOFs that span capturing carbon dioxide from the atmosphere, separating and storing gases, and decontaminating water and soils. These technologies offer industry significant productivity and environmental benefits.
Later this year, Dr Liang will join fellow CSIRO colleague Dr Paul Berkman and 11 other young Australians who were selected to attend the 65th Lindau Nobel Laureate Meeting – the Oscars equivalent of the science world.
Measuring Neutrophil Motility Could Lead to Accurate Sepsis DiagnosisNews
Mass. General researchers design device that rapidly diagnoses sepsis with more than 95 percent accuracy.READ MORE
Malaria Prevention: New Antibody Targets Unique Binding SiteNews
Scientists have discovered a human antibody that, when tested in mice, prevented malaria infection by binding a specific portion of a surface protein found in almost all strains of the malaria parasite worldwide.READ MORE
H7N9 Influenza Vaccine Clinical Trials CommenceNews
Two new clinical trials testing an experimental vaccine to prevent influenza caused by an H7N9 influenza virus are now enrolling volunteers at sites across the United States. The Phase 2 studies will test different dosages of the inactivated influenza vaccine candidate as well as different vaccination schedules. The studies also will evaluate whether an adjuvant boosts the immune responses of people receiving the vaccine.
Comments | 0 ADD COMMENT
World Congress on Advanced Pharmacy and Clinical Research
Jul 16 - Jul 17, 2018
6th Annual Congress on Biology and Medicine of Molecules
Sep 17 - Sep 18, 2018
International Conference on Molecular Biology and Stem Cells
Aug 13 - Aug 15, 2018
World Congress on Plant Science and Molecular Biology
Sep 12 - Sep 13, 2018