We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience, read our Cookie Policy

Small Populations of Normal Cells Affect Immunity in Patients with XLP1

News   Nov 12, 2018 | Original Story from the Tokyo Medical and Dental University.

 
Small Populations of Normal Cells Affect Immunity in Patients with XLP1

This slide illustrates a model of cellular and humoral immunity regarding SAP. In normal individuals, SAP+ CD8+ T cells attack EBV-infected B cells via IFN-gamma, perforin, and granzyme, and EBV-infected B cells lead to cell death. SAP+ CD4+ T cells help immunoglobulin production from B cells via IL-10 and ICOS. In XLP1 patients, the SAP function is completely impaired, and the patients develop FIM or HLH and hypo- or dysgammglobulinemia. In XLP1 patients with somatic reversion, as demonstrated in this study, small populations of SAP+ T cells can rescue the function. The patients were not associated with FIM or HLH, and they presented with IgG3 and IgG4 deficiency only. Credit: Department of Child Health and Development,TMDU.

 
 
 

RELATED ARTICLES

3D Printed Microfluidic Device Simulates Cancer Treatments

News

Inexpensive 3-D-printed microfluidics device could be used to personalize cancer treatment. A key feature in this MIT-designed device was using a new biocompatible resin — traditionally used for dental applications — that can support long-term survival of biopsied tissue.

READ MORE

Probiotic Gives Long-standing Protection Against Childhood Eczema

News

Giving a probiotic supplement to pregnant mothers and their infants significantly reduces the chances of a child developing eczema for the first 11 years of their life.

READ MORE

Promise for an HIV Vaccine

News

An experimental vaccine strategy against HIV has been shown to work in non-human primates.

READ MORE

 

Like what you just read? You can find similar content on the communities below.

Cell Science

To personalize the content you see on Technology Networks homepage, Log In or Subscribe for Free

LOGIN SUBSCRIBE FOR FREE