TopiVert Starts Phase I Clinical Trial in Ulcerative Colitis
News May 19, 2015
Imperial Innovations Group plc notes that portfolio company TopiVert Pharma Ltd (TopiVert or the ‘Company’) has started a Phase I study with its lead compound, TOP1288, in ulcerative colitis (UC) a common inflammatory disease affecting the large bowel.
TOP1288 is a Narrow Spectrum Kinase Inhibitor (NSKI) a novel class of small molecules with specific characteristics designed to deliver local effects in inflammatory cells whilst avoiding significant systemic exposure.
TopiVert is clinical-stage biotech focused on pioneering topical treatments for serious inflammatory diseases. The Company was formed in December 2011, following an investment of £8.0m by Innovations and SV Life Sciences.
In December 2013, TopiVert raised a further £17.0 million in a funding round which brought in new investors Johnson & Johnson Development Corporation and Neomed Management, alongside Innovations and SV Life Sciences.
At 31 January 2015, the Group had a 33.1% interest in TopiVert with a fair value of £6.0million.
Maina Bhaman, Director of Healthcare Ventures, Imperial Innovations said, “We are delighted with the progress that TopiVert’s experienced management team has made in taking its first product into the clinic.
“Ulcerative Colitis is a debilitating condition that arises because the body’s immune system is triggered to produce an inflammatory reaction in the intestinal tract that leads to damage of the intestinal wall. It is commonly treated with corticosteroids but for many patients this proves to be unsatisfactory either because they fail to respond or because they become dependent upon steroids to maintain disease remission.
“For such patients the current option is to move to an immunosuppressant or a systemic biologic treatment. However, TopiVert is developing a novel topical treatment which could provide a locally acting drug in the colon without systemic side effects. This would provide significant relief for many sufferers of this disease.”
H7N9 Influenza Vaccine Clinical Trials CommenceNews
Two new clinical trials testing an experimental vaccine to prevent influenza caused by an H7N9 influenza virus are now enrolling volunteers at sites across the United States. The Phase 2 studies will test different dosages of the inactivated influenza vaccine candidate as well as different vaccination schedules. The studies also will evaluate whether an adjuvant boosts the immune responses of people receiving the vaccine.
Study Extends Potential of Personalized Cell-based ImmunotherapiesNews
New methods developed for the study could be applied to devise personalized, cell-based immunotherapies for epithelial ovarian cancer or other types of tumorsREAD MORE
Hope for Hot Flushes: New Class of Menopause Drugs Reduces SeverityNews
A new class of experimental drugs reduces hot flushes in menopausal women by almost three-quarters in just three days. The new analysis, published in the journal Menopause, also revealed sleep and concentration significantly improved in the three-day window.