We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
What Causes Immune Cell Migration To Wounds
News

What Causes Immune Cell Migration To Wounds

What Causes Immune Cell Migration To Wounds
News

What Causes Immune Cell Migration To Wounds

Read time:
 

Want a FREE PDF version of This News Story?

Complete the form below and we will email you a PDF version of "What Causes Immune Cell Migration To Wounds"

First Name*
Last Name*
Email Address*
Country*
Company Type*
Job Function*
Would you like to receive further email communication from Technology Networks?

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

Immune cells play an important role in the upkeep and repair of our bodies, helping us to defend against infection and disease. Until now, how these cells detect a wounded or damaged site has largely remained a mystery. New research, led by University of Bristol academics in collaboration with a team from the University of Sheffield, has identified the triggers which lead these cells to react and respond in cell repair.

It is hoped the findings, published in Current Biology, could help scientists design therapies to manipulate the cell repair process and direct immune cells away from sites where they are doing damage, such as tumours, and send them to places where they are needed.

Previous studies had found that the earliest signal produced at a wound site responsible for attracting immune cells to the damaged site is hydrogen peroxide (H2O2). However, it was still unclear how these cells detect this chemical, and what signalling occurs in these cells downstream of H2O2 detection to power their rapid migration. 

Using the common fruitfly (Drosophila melanogaster) and timelapse microscopy, the team led by Professor Will Wood at the University of Bristol were able to study the process in situ and identify what causes the cells to migrate to sites of damage where they then detect, ingest and degrade debris, dying cells and invading pathogens.

After dissecting the signalling occurring in immune cells responding to wound induced (H2O2), the team found that it involved a well-established immune signalling pathway used in vertebrate adaptive immune responses. The results suggest that adaptive immune signalling pathways important in distinguishing self from non-self in vertebrates appear to have evolved from a more ancient response designed to distinguished ‘damaged self’ from ‘healthy self’.

Will Wood, Professor of Developmental Biology, in Bristol’s School for Cellular and Molecular Medicine in the Faculty of Medical and Veterinary Sciences and the study’s lead author, said: “While inflammation is critical to prevent infection, too much of a response by immune cells can cause or worsen a wide range of human diseases and conditions including autoimmunity, atherosclerosis, cancer and chronic inflammation.

“This research is therefore critical for improving human health as it enables us to discover novel points of intervention to manipulate immune cell behaviour and allow us to design therapies to direct immune cells away from sites where they are doing damage and send them into places where they are needed.”  

Advertisement