Amoebic Meningoencephalitis: Etiology, Infection and Prevention
Poster Dec 13, 2017
Jafar Ahmed, Nazeer Hyder, Christopher Meusburger, Nicole Rosteski, Nicole Sottile, & Tyler Welch
Amoebic Meningioencephalitis generally presents in two ways. The first way is primary amoebic meningioencephalitis (PAM), which is caused by infected water containing amoeba Naegleria fowleri entering the nasal passage and penetrating the olfactory mucosa. This organism usually strikes children, with 83% of those who have contracted it being under eighteen years old. This disease is rapidly developing, and patients who do not receive treatment inside the first 48 hours will expire. Immediate treatment consists of miltefosine coupled with voriconazole and ice packs to decrease the patient's intense fever and combat the invasive amoeba. The second type of amoebic meningioencephalitis, which involves the Acanthamoeba spp. and Balamuthia mandrillasis, is granulomatous amoebic meningioencephalitis. This type strikes immunocommpromised patients with generally the same outcome and treatment type.
Genome-wide association studies (GWAS) have identified more than 100 genetic loci associated with type 2 diabetes. The majority of these are located in the intergenic or intragenic regions suggesting that the implicated variants may alter chromatin conformation. This, in turn, is likely to influence the expression of nearby or more remotely located genes to alter beta cell function. At present, however, detailed molecular and functional analyses are still lacking for most of these variants. We recently analysed one of these loci and mapped five causal variants in an islet-specific enhancer cluster within the STARD10 gene locus. Here, we aimed to understand how these causal variants influence b-cell function by alteration of the chromatin structure of enhancer clusterREAD MORE
Human papillomavirus (HPV) vaccine rates continue to be low in the United States. Young women ages 18-26 years are eligible for catch-up vaccination but previous research shows that relationships status and percieved risk may be barriers to HPV vaccination. The purpose of this quantitative study was to assess the association between relationship status and perceived risk for HPV among young adult women.READ MORE
This abstract discusses three cases of pediatric heart transplant patients who suffered from parvovirus (B19) infection. Of these patients, two ( B & C) responded well to standard intravenous Ig therapy. Patient A however, did not respond to standard treatment and was begun on subcutaneous Ig, which effectively diminished his viral load. Thus, subcutaneous Ig infusions might serve as a second line treatment for transplant patients with parvovirus who do not respond well to the standard approach.READ MORE