Evaluating Florida Systems of Care for Zika Infected Individuals
Poster May 08, 2018
Carlos Parra, Jennifer Delva, Dogeli Rojas, Jennifer Marshall
We followed the Florida Department of Health Zika process maps for women seeking testing and health care services for Zika positive status during pregnancy. Using the journey mapping strategy, our team "walked" the same path a mother seeking testing would follow and conducted interviews with those who are on the front lines of the systems. By dividing the systems into two: "Point-of-care" and "Outbreak Management", we were better able to separate and study the strengths in the systems and challenges the state had to handle. Interviews and focus groups were then analyzed by means of MAXQDA software. Using a modified version of the WHO Health systems evaluation framework, we coded the interviews for recommendations that can be addressed to each of the six building blocks that make up an effective health delivery system.
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Genome-wide association studies (GWAS) have identified more than 100 genetic loci associated with type 2 diabetes. The majority of these are located in the intergenic or intragenic regions suggesting that the implicated variants may alter chromatin conformation. This, in turn, is likely to influence the expression of nearby or more remotely located genes to alter beta cell function. At present, however, detailed molecular and functional analyses are still lacking for most of these variants. We recently analysed one of these loci and mapped five causal variants in an islet-specific enhancer cluster within the STARD10 gene locus. Here, we aimed to understand how these causal variants influence b-cell function by alteration of the chromatin structure of enhancer clusterREAD MORE