T-helper cell phenotype expression in cutaneous lesions of angioimmunoblastic T-cell lymphoma
Poster May 09, 2018
Nupur Patel BS, John Denigris MD, Tania Mendoza MD, Lubomir Sokol MD, PhD, and Lucia Seminario-Vidal MD, PhD
Angioimmunoblastic T-cell lymphoma (AITL) is a common type of peripheral T-cell lymphoma. AITL can be missed until lymphadenopathy develops in patients initially presenting with skin lesions, as skin biopsy may lack conclusive findings. The expression of follicular helper T-cell (THF) markers in the skin can be an important diagnostic clue. We present a case of AITL with skin lesions positive for CD10 and dim PD1 T-cells, with the purpose of highlighting the potential for diagnosing cutaneous AITL via skin biopsy.
71-year old Caucasian male presented for second opinion of his skin lesions. On exam, there were firm nodules throughout his body with enlarged lymph nodes on bilateral axillae. Skin biopsies demonstrated nodular proliferation of atypical lymphoid cells with perivascular and periadnexal infiltration. Staining revealed more prominent B-cell lymphoproliferative, while limited T-cell infiltrate expressed TFH markers, CD10 and PD1, suggestive of TFH origin. Fine needle aspiration of lymph node revealed an aberrant T cell population. Peripheral blood flow cytometry and bone marrow analyses also identified abnormal T cell population with TFH phenotype. Based on overall findings and pathology, diagnosis of AITL was made.
Our case highlights the extranodal presentation of AITL with cutaneous lesions displaying the TFH phenotype. Although AITL and the presence of TFH markers is generally studied via lymph node biopsy, the disease often presents with prominent skin findings that can be diagnosed via biopsy. Further insight into markers specific for cutaneous AITL may lead to advances in diagnostic strategies and clinical outcomes of AITL.
Treatment Options for Chronic Parvovirus Viremia in Pediatric Heart Transplant Patients in a Tertiary Care CenterPoster
This abstract discusses three cases of pediatric heart transplant patients who suffered from parvovirus (B19) infection. Of these patients, two ( B & C) responded well to standard intravenous Ig therapy. Patient A however, did not respond to standard treatment and was begun on subcutaneous Ig, which effectively diminished his viral load. Thus, subcutaneous Ig infusions might serve as a second line treatment for transplant patients with parvovirus who do not respond well to the standard approach.READ MORE
The Utility of Pediatric Asthma Severity Scores in Disposition Decisions for Status AsthmaticusPoster
We aimed to determine if the Pediatric Asthma Severity Score (PASS) predicts a patient's appropriate level of care in the inpatient setting, with special attention to patients who required rapid transfer to another level of care after initial disposition and/or hospital readmission.READ MORE
Regulatory T-Cells (Tregs) Within Bone Marrow-Derived Stem Cells (BMSCs) Actively Confer Immunomodulatory and Neuroprotective Effects Against StrokePoster
We found a distinct subpopulation of Tregs within BMSCs. Tregs and BMSCs in co-culture conferred neuroprotection that varied in a dose-dependent manner. Tregs minimized stem cell production of IL-6, a pro-inflammatory cytokine, and inhibited BMSC secretion of FGF-beta, a cytokine related to BMSC proliferation and differentiation. The ratio of Tregs found natively in BMSCs is optimally adapted to provide the maximum neuroprotective benefit of stem cell treatment after ischemic stroke.READ MORE
Comments | 0 ADD COMMENT
International Conference on Biobetters and Regulatory Affairs
Jun 27 - Jun 28, 2018