AAV Therapy Approach Reveals Source of Arthritis Pain

Amsbio reports how researchers from the Karolinska Institute, Stockholm, Sweden are using their Adeno Associated Virus (AAV) products in a groundbreaking investigation into the causes of Rheumatoid Arthritis pain.

Rheumatoid arthritis (RA) pain is not explained well by inflammation alone. In a new peer reviewed study the Swedish researchers describe the multitude of approaches they used to uncover the neural basis and causes of the inflammatory pain. In one described methodology the researchers used AAV produced by Amsbio for conditional Ifnar1 knockout in sensory neuron and pharmacological inhibition, which lead to alleviation of joint pain and restoration of dexterity and paw function.

This pioneering AAV approach let the researchers functionally interrogate the exact joint-innervating neurons, rather than inferring joint involvement from skin sensitivity or broad Dorsal Root Ganglion manipulation.

The authors of the paper conclude that joint pain in RA is caused by a defined cytokine and signalling pathway and holds promise for targeted therapies for pain relief in arthritis.

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