Abcore® Launches Naturally-Derived VHH Library Anti-T-Cell Platform

Abcore®, a brand operating within the Antibody Solutions (AbS) business division as a part of Fortis Life Sciences™, an innovation leader in VHH discovery and single-domain-antibody library construction, announces the launch of AbNano™ Anti-T-Cell VHH Library, strengthening its VHH platform solutions. The Anti-T-Cell Library builds on the success of Abcore’s previously released AbNano™ Naïve VHH Library and expands innovative capabilities in immunology-focused research discovery.

The AbNano™ Anti-T-Cell Library is a first-in-class, naturally-derived VHH library designed for rapid identification of antibodies that bind to native T-cell surface proteins. With a target-binding population estimated one billion unique VHH molecules, the library enables direct access to novel binding profiles difficult and time consuming to generate using traditional methods.

“Abcore’s novel AbNano™ Anti-T-Cell Library enables rapid early therapeutic discovery for research labs, biotech companies, and pharma,” said Sam Sugerman, Director of VHH Discovery at Fortis Life Sciences. “By combining error-prone PCR diversification with whole, unstimulated T-Cells, Abcore has developed an effective library that reveals unique binding modalities applicable across bioprocessing, diagnostics and early-stage therapeutic discovery.”

T-Cells present unique challenges for antibody discovery due to the complex and context-sensitive nature of their surface proteins. The AbNano™ Anti-T-Cell library is an experimental solution that solves that challenge by utilizing:

• Native T-Cell-based immunization strategy reducing late-stage attrition
• Error-prone PCR (epPCR) diversification probing novel sequences
• Diverse and atypical binding modes creating unique solutions
• Validated key binders for critical targets, including CD3ε and CD8αβ

With applications spanning bioprocess optimization to preclinical therapeutic research discovery, the library is available to partners through Abcore’s early access program.

Flexible Engagement with Promotional Launch Packages

To support accelerated research discovery efforts, Abcore is offering limited-time promotional packages for partners to evaluate the AbNano™ VHH Libraries:

• Solid-Phase Panning or Solution-Phase Panning