AnaSpec Introduces SensoLyte® a-Synuclein ELISA Assay
Product News Apr 17, 2012
AnaSpec, EGT Group has announced the release of an ultrasensitive ELISA assay for quantitatingα-synuclein.
The SensoLyte® α-Synuclein Quantitative ELISA Kit (Human/Mouse/Rat) provides a convenient and quantitative assay for determining α-Synuclein amount in cell and tissue lysate as well as in body fluids.
Compared to other anti-α-Synuclein ELISA kits on the market, this one-step, mix-and-read assay takes less time to run.
HRP conjugated detection antibody is added simultaneously with the samples and standards during the assay, eliminating extra incubation and washing steps.
α-Synuclein is a major component of Lewy bodies found in affected neurons of patients with Parkinson’s disease.
This protein has a mass of 14.5 kDa (140 amino acids long) and consists of a conserved degenerative amino-terminal domain and an acidic carboxyl-terminal that has a higher sequence divergence.
α-Synuclein is predominantly expressed in brain, specifically in cerebellum, thalamus, neocortex, hippocampus, and striatum regions.
Other tissues also express α-Synuclein but at very low levels. The physiological role of α-Synuclein is not well understood.
However, the presence of imperfect KTKEGV lipid interacting repeats suggests that it may be involved in synaptic vesicle homeostasis.