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TTP LabTech Launch Triple Laser Microplate Cytometer
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TTP LabTech has announced that it has initiated the second generation of high content screening systems with the launch of the triple laser Acumen® eX3 microplate cytometer at SBS 2006.
An evolution of its Acumen Explorer® HCS platform technology, the Acumen® eX3 is equipped with up to three lasers at 405, 488 and 633 nm, offering a wavelength range for excitation that is similar to that of white light source instrumentation and increasing the variety of fluorescent reagents compatible with the system.
Company claims that, the Acumen® eX3 will simplify assay transfer from development to screening laboratories by delivering the object recognition of CCD Imagers combined with the fast reads of bulk fluorescence readers.
Scanning up to 64 whole wells at a time, the Acumen range of laser-scanning fluorescence microplate cytometers can perform cytometric analyses at throughputs of up to 200 plates - or 300,000 data points (1536 plates) - per day.
Putting the development of the Acumen® eX3 in context, Wayne Bowen, TTP LabTech’s CSO said, "The Acumen Explorer® is routinely relied on for high content screening in industry and academia because of its unique ability to combine data collection from whole well scanning with fast read times."
"The Acumen® eX3 offers huge flexibility: researchers can select the optimum laser combination required to excite the fluorescent probes being used."
"Since nuclear staining is not required to locate the cells, all probes may be used for reporting biological responses."
"The upshot is that, with simultaneous four colour detection, the Acumen® eX3’s possible performance exceeds the limits of current multicolour, multiplexed assay protocols, giving an assurance of future-proofing."
The Acumen® eX3’s enhanced software gives the added flexibility of exporting TIFF images which closely match those captured using a 20x microscope objective for subsequent analysis by third party image analysis software.
This facilitates the transfer from assay development on microscope-based CCD Imagers to assay screening on the Acumen® eX3 with minimal changes to experimental protocols.
Flexibility is further assured since the Acumen® eX3’s functionality can be built-up over time, starting with one laser and retrospectively adding additional lasers, depending on user or assay requirements.
