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ACE2 Mouse Models for Studying COVID-19 Immunology
Product

ACE2 Mouse Models for Studying COVID-19 Immunology

ACE2 Mouse Models for Studying COVID-19 Immunology
Product

ACE2 Mouse Models for Studying COVID-19 Immunology

As researchers investigate the implications of ACE2 in COVID-19 pathology, different animal models may be needed to explore the mechanisms of ACE2 in its entirety. There are multiple approaches to developing humanized ACE2 (hACE2) models, including ROSA26 conditional knockin (cKI) or endogenous replacement, which yield different proteins. Given the early stages of most ACE2 research performed in animal models, there has yet to be sufficient evidence to determine the explicit advantages of either humanized model generation method.

Despite these challenges, using a variety of animal models can serve to elucidate the function of ACE2 in COVID-19 onset. Mouse models are useful in research efforts across viral pathogenesis and disease pathology, serving as effective platforms for testing vaccines and antiviral therapies. Comparing results across both hACE2 models and background strains will help collective efforts to understand how each model serves to recapitulate both the virology of SARS-CoV-2 and pathology of COVID-19 in humans.

To support this approach, Cyagen is offering a bundle discount of 10% off when ordering mice from across ACE2 model generation methods and/or strain backgrounds. Get any combination of hACE2 or ACE2 KO models in either C57BL/6J or BALB/c strain backgrounds to qualify for the savings.

Additionally, we are excited to be able to provide several technical reports about the progress on these ACE2 models, which are estimated to be available to researchers in as soon as 2 months.

ACE2 Catalog Models

Backgrounds

Price ($) per Mouse

Bundle Discount Offer

Knockout (KO)

C57BL/6J

$500

Order 10 Mice to Save 10%

Choose any combination of ACE2 catalog models

BALB/c

$650

Humanized Mice (ROSA26 cKI)

C57BL/6J

$1,000

BALB/c

$1,300

Humanized Mice (Endogenous Replacement)

C57BL/6J

$1,200

BALB/c

$1,500

Visit our page to request the PCR genotyping reports for these ACE2 models and learn more about this offer.

Beyond ACE2: Additional Targets of Significance for Coronavirus Research

At present, the prevention and treatment of the novel coronavirus is the most urgent issue for scientific and medical research. Our experts have investigated the lesser-known targets that are pertinent to coronavirus research, listed below. For the comprehensive analysis of COVID-19 research targets, request our complementary white paper.


Beyond ACE2: Additional Targets of Significance for Coronavirus Research

DPP4
(Dipeptidyl peptidase 4)
KO/cKO/Humanized Mice

APN
(Aminopeptidase N)
KO/cKO/Humanized Mice

TMPRSS2
(Transmembrane Serine Protease 2)
KO/cKO/Humanized Mice

ADAM17
(ADAM Metallopeptidase Domain 17) KO/cKO/Humanized Mice

LY6E
(Lymphocyte Antigen 6 Complex, Locus E) KO/cKO/Humanized Mice

SIGN/CD209L
(Cluster of Differentiation 209)

KO/cKO/Humanized Mice

CD147
(Cluster of Differentiation 147)

KO/cKO/Humanized Mice

DHODH
(Dihydroorotate Dehydrogenase)

KO/cKO/Humanized Mice


In addition to above targets, if you would like to order any other models related to the research of SARS-CoV-2 (COVID-19), Cyagen can provide the relevant gene knockout (KO), knock-in (KI), conditional knock-out (cKO), point mutation, and humanized mice models to facilitate your research goals. Our genetic engineering experts are readily available to consult on your model generation project and provide you with a free targeting strategy, quote, and an official letter of support for your research funding applications. Contact us for your free consultation and we will follow-up within 48 hours.

Company Details
Cyagen US Inc
2255 Martin Avenue
Suite E
Santa Clara
CA
95050-2709
US
Tel: 1 800-921-8930
Fax: 1 408-969-0336
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