ACE2 Mouse Models for Studying COVID-19 Immunology
As researchers investigate the implications of ACE2 in COVID-19 pathology, different animal models may be needed to explore the mechanisms of ACE2 in its entirety. There are multiple approaches to developing humanized ACE2 (hACE2) models, including ROSA26 conditional knockin (cKI) or endogenous replacement, which yield different proteins. Given the early stages of most ACE2 research performed in animal models, there has yet to be sufficient evidence to determine the explicit advantages of either humanized model generation method.
Despite these challenges, using a variety of animal models can serve to elucidate the function of ACE2 in COVID-19 onset. Mouse models are useful in research efforts across viral pathogenesis and disease pathology, serving as effective platforms for testing vaccines and antiviral therapies. Comparing results across both hACE2 models and background strains will help collective efforts to understand how each model serves to recapitulate both the virology of SARS-CoV-2 and pathology of COVID-19 in humans.
To support this approach, Cyagen is offering a bundle discount of 10% off when ordering mice from across ACE2 model generation methods and/or strain backgrounds. Get any combination of hACE2 or ACE2 KO models in either C57BL/6J or BALB/c strain backgrounds to qualify for the savings.
Additionally, we are excited to be able to provide several technical reports about the progress on these ACE2 models, which are estimated to be available to researchers in as soon as 2 months.
| ACE2 Catalog Models | Backgrounds | Price ($) per Mouse | Bundle Discount Offer |
| Knockout (KO) | C57BL/6J | $500 | Order≥ 10 Mice to Save 10% |
| BALB/c | $650 | ||
| Humanized Mice (ROSA26 cKI) | C57BL/6J | $1,000 | |
| BALB/c | $1,300 | ||
| Humanized Mice (Endogenous Replacement) | C57BL/6J | $1,200 | |
| BALB/c | $1,500 |
Visit our page to request the PCR genotyping reports for these ACE2 models and learn more about this offer.
Beyond ACE2: Additional Targets of Significance for Coronavirus Research
At present, the prevention and treatment of the novel coronavirus is the most urgent issue for scientific and medical research. Our experts have investigated the lesser-known targets that are pertinent to coronavirus research, listed below. For the comprehensive analysis of COVID-19 research targets, request our complementary white paper.
Beyond ACE2: Additional Targets of Significance for Coronavirus Research | |
| DPP4 | APN |
| TMPRSS2 | ADAM17 |
| LY6E | SIGN/CD209L KO/cKO/Humanized Mice |
| CD147 KO/cKO/Humanized Mice | DHODH KO/cKO/Humanized Mice |
In addition to above targets, if you would like to order any other models related to the research of SARS-CoV-2 (COVID-19), Cyagen can provide the relevant gene knockout (KO), knock-in (KI), conditional knock-out (cKO), point mutation, and humanized mice models to facilitate your research goals. Our genetic engineering experts are readily available to consult on your model generation project and provide you with a free targeting strategy, quote, and an official letter of support for your research funding applications. Contact us for your free consultation and we will follow-up within 48 hours.
