Duet Multiomics Solution evoC

Reveal the power of the 6-base genome with duet multiomics solution evoC. The combinatorial genetic and epigenetic technology provides single-base-resolution sequencing data that reveals standard four-base sequencing (A, G, C, and T), and distinguishes between 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC), on the same DNA molecule. This added resolution will allow greater power in detecting disease associations, identifying novel biomarkers, developing disease classifiers, and monitoring the progression of disease; even with limited samples such as cell-free DNA (cfDNA).  

The advanced 6-base genome data enables the exploration of epigenetic mechanisms of gene regulation through methylation and hydroxymethylation. Researchers now are able to obtain an accurate measurement of 5mC and 5hmC, integrated into local genetic context, with >95% of bases above Q30 and 50% with accuracy above Q40. By measuring multiple modes of biology from a single low-input DNA sample in a single experiment, researchers can use the comprehensive data to build predictive models of gene expression, chromatin accessibility, and enhancer status to better understand the biological mechanisms that link genotype to phenotype.