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Glial cell line-derived neurotrophic factor (GDNF) plays a vital role in promoting motor neuron survival and axon outgrowth. It is being evaluated in clinical trials as a potential therapeutic for Parkinson’s disease. GFL-like drugs are also being developed to treat disorders such as neuropathic pain and addiction.
GDNF belongs to the GDNF family of ligands (GFLs), which also consists of neurturin (NRTN), artemin (ARTN), and persephin (PSPN). These molecules bind to GFRA1, GFRA2, GFRA3, and GFRA4, respectively. GDNF/GFRA1 complex triggers the phosphorylation of RET tyrosine kinase receptor, ultimately eliciting cell survival, proliferation, and development via the MAPK/ERK or PI3K/Akt pathways. GDNF/GFRA1 also complexes with NCAM to induce axonal expansion. In addition, GDNF can synergize with other growth factors, including transforming growth factor-β (TGF-beta).
Sino Biological has developed an array of recombinant GDNF and GFRA1 proteins and antibodies from various species, such as human, mouse, cynomolgus, rabbit, rat, and canine.
About Sino Biological
Sino Biological is an international reagent supplier and contract research service provider. The company specializes in recombinant protein production and antibody development. All of Sino Biological's products are independently developed and produced with a stringent quality management system, and include unique bioreagents addressing areas such as cell therapy, stem cell, and infectious disease research. For example, Sino Biological has a wealth of viral antigens (Provir®) and corresponding antibodies, with one of the world’s Extensive collections. Sino Biological is also a well-recognized, qualified source of recombinant cytokines and high-quality GMP-grade cytokines. In addition, Sino Biological offers contract research production services for the custom development of full length, bioactive proteins and high-affinity antibodies, along with other services. To learn more about Sino Biological visit www.sinobiological.com, follow us on LinkedIn or @SinoInc on Twitter.
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