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GMP Human 4-1BB Ligand Protein for T, NK, and DC Cell Culture

GMP Human 4-1BB Ligand Protein for T, NK, and DC Cell Culture

4-1BB Ligand (4-1BBL) is an immune stimulatory molecule that interacts with 4-1BB receptor during antigen presentation, exerting a pleiotropic influence on the immune system. Its in vitro functions include the following:

1. T cell activation and proliferation

Conventionally, the first and second stimulation signals in vitro, simulating the process in vivo, are achieved using anti-CD3 antibody, anti-CD28 antibody, or CD3/CD28 magnetic beads, along with the addition of relevant growth factors to activate T cells. During this process, the CD28-mediated co-stimulatory signal plays a central role. Multiple studies have now demonstrated that 4-1BBL can independently provide co-stimulatory signals to induce T cell proliferation, separate from CD28 molecule signaling.

Our other products for T cell activation and expansion:

GMP Grade anti-CD3 Antibody, GMP Grade Anti-human CD3/CD28 magnetic beads, GMP Grade IL-2, IL-7, IL-15, IL-21, etc.

2. Enhance NK cell proliferation and cytotoxicity

Studies have shown a significant enhancement of NK cell proliferation and cytotoxicity with 4-1BBL, which triggers 4-1BB signaling to stimulate NK cell proliferation and IFN-γ secretion. 4-1BBL is often co-administered with other cytokines to enhance the activation of NK cells.

3. Augment DC antigen presentation

DCs stimulated by 4-1BBL express higher levels of immune co-stimulatory molecules (such as CD80, CD83, HLA-DR) compared to DCs stimulated by TNF-a, indicating that 4-1BBL-stimulated DCs possess stronger antigen presentation ability and the capacity to initiate specific T cell and B cell immune responses.

We now offer free sample requests of GMP Human 4-1BB Ligand Protein and other products including cytokines, antibodies, beads, nuclease and enzymes.

Click here to learn more and request a sample of whatever you need!

About ACROBiosystems
ACROBiosystems is a cornerstone enterprise of the pharmaceutical and biotechnology industries. Our mission is to help overcome challenges with innovative tools and solutions from discovery to the clinic. We supply life science tools designed for discovery research and scalable to the clinical phase and beyond. By consistently adapting to new regulatory challenges and guidelines, we deliver solutions, whether it comes through recombinant proteins, antibodies, assay kits, GMP-grade reagents, or custom services. We empower scientists and engineers dedicated to innovation to simplify and accelerate the development of new, better, and more affordable medicine. Our way of addressing challenges in biologics development is to offer a comprehensive array of tools and solutions designed for each development phase. Starting from discovery and development and moving beyond commercialization, we strive to deliver high-quality solutions that support each step of the development process. This means bringing together innovation and technology through product development and collaborations to help our customers achieve translatable results in the clinic and beyond.
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