IL1-Beta Primes Innate Immunity
The innate immunity, mediated by IL1 family proinflammatory cytokines, is the first line of defense against infections. Interleukin-1β (IL-1β), along with IL1-alpha and IL18, orchestrate the immune response through multiple downstream mechanisms. IL1-beta participates in the regulation of IL6 and TNF-alpha, and it also activates the vascular adhesion molecules ICAM1.
IL1-beta transduces its signal through binding with the receptor IL1RI, which is complexed with the accessory protein IL1RACP. IL1-beta signaling is negatively regulated by the decoy receptor IL1-RII, and the receptor antagonist IL1RA.
- IL-1β Proteins
- ELISA Antibodies: 10139-R012, 10139-R101
- ELISA Antibody pair- Capture: 10139-MM07, Detection: 10139-MM09