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IL1-Beta Primes Innate Immunity
The innate immunity, mediated by IL1 family proinflammatory cytokines, is the first line of defense against infections. Interleukin-1β (IL-1β), along with IL1-alpha and IL18, orchestrate the immune response through multiple downstream mechanisms. IL1-beta participates in the regulation of IL6 and TNF-alpha, and it also activates the vascular adhesion molecules ICAM1.
IL1-beta transduces its signal through binding with the receptor IL1RI, which is complexed with the accessory protein IL1RACP. IL1-beta signaling is negatively regulated by the decoy receptor IL1-RII, and the receptor antagonist IL1RA.
- IL-1β Proteins
- ELISA Antibodies: 10139-R012, 10139-R101
- ELISA Antibody pair- Capture: 10139-MM07, Detection: 10139-MM09
About Sino Biological
Sino Biological is an international reagent supplier and contract research service provider. The company specializes in recombinant protein production and antibody development. All of Sino Biological's products are independently developed and produced with a stringent quality management system, and include unique bioreagents addressing areas such as cell therapy, stem cell, and infectious disease research. For example, Sino Biological has a wealth of viral antigens (Provir®) and corresponding antibodies, with one of the world’s Extensive collections. Sino Biological is also a well-recognized, qualified source of recombinant cytokines and high-quality GMP-grade cytokines. In addition, Sino Biological offers contract research production services for the custom development of full length, bioactive proteins and high-affinity antibodies, along with other services. To learn more about Sino Biological visit www.sinobiological.com, follow us on LinkedIn or @SinoInc on Twitter.
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