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Sino Biological Inc

IL1-Beta Primes Innate Immunity

IL1-Beta Primes Innate Immunity


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Sino Biological Inc

The innate immunity, mediated by IL1 family proinflammatory cytokines, is the first line of defense against infections. Interleukin-1β (IL-1β), along with IL1-alpha and IL18, orchestrate the immune response through multiple downstream mechanisms. IL1-beta participates in the regulation of IL6 and TNF-alpha, and it also activates the vascular adhesion molecules ICAM1.

IL1-beta transduces its signal through binding with the receptor IL1RI, which is complexed with the accessory protein IL1RACP. IL1-beta signaling is negatively regulated by the decoy receptor IL1-RII, and the receptor antagonist IL1RA.

Sino Biological has developed a panel of recombinant IL-1β and IL-1β receptor reagents for the studying of the innate immune response.